de Beaufort C E, André J L, Heimans J J, van der Eerden H A, van Diemen N G, Duc M L, Pierson M
Department of Paediatrics I, CHU Brabois, Nancy, France.
Pediatr Nephrol. 1989 Apr;3(2):175-8. doi: 10.1007/BF00852903.
Information on clinical and subclinical peripheral neuropathy in children with end-stage renal failure (ESRF) is scarce. We have studied the presence of clinical and subclinical peripheral neuropathy in children with ESRF comparing recently developed non-invasive methods with the measurement of nerve conduction velocities. Twelve children (7 boys, 5 girls; age range: 5-17 years; duration of haemodialysis: 0.5-60 months) participated. Thermal discrimination threshold (TDT) and vibration perception threshold (VPT) were determined twice before and after haemodialysis in each patient. Peroneal nerve conduction velocity was determined once before haemodialysis. No clinical or subclinical peripheral neuropathy was observed in any of the children. Except for two slightly increased TDT values after haemodialysis all results were within the normal range. No correlation was found with age or duration of haemodialysis and no association was found between the three methods. VPT values showed a significant improvement after haemodialysis treatment, although all VPT values were in the normal range. This suggests that haemodialysis has an influence on cutaneous sensation, but further study is needed to confirm this observation. Longitudinal investigations will be necessary to evaluate whether TDT and VPT determinations can be used for early screening of clinical and subclinical neuropathy in children with ESRF.
关于终末期肾衰竭（ESRF）患儿临床及亚临床周围神经病变的信息匮乏。我们通过比较最近开发的非侵入性方法与神经传导速度测量，研究了ESRF患儿临床及亚临床周围神经病变的情况。12名儿童（7名男孩，5名女孩；年龄范围：5 - 17岁；血液透析时间：0.5 - 60个月）参与了研究。在每次血液透析前后，对每位患者进行两次热觉辨别阈值（TDT）和振动觉阈值（VPT）测定。在血液透析前对腓总神经传导速度进行一次测定。所有儿童均未观察到临床或亚临床周围神经病变。除了血液透析后有两个TDT值略有升高外，所有结果均在正常范围内。未发现与年龄或血液透析时间相关，且三种方法之间未发现关联。尽管所有VPT值均在正常范围内，但血液透析治疗后VPT值有显著改善。这表明血液透析对皮肤感觉有影响，但需要进一步研究来证实这一观察结果。有必要进行纵向研究，以评估TDT和VPT测定是否可用于ESRF患儿临床及亚临床神经病变的早期筛查。
