Parren Paul W H I, Burton Dennis R, Bradbury Andrew, Huston James S, Carter Paul J, Veldman Trudi, Chester Kerry A, Larrick James W, Alfenito Mark R, Scott Jamie K, Weiner Louis M, Adams Gregory P, Reichert Janice M
a Genmab; Utrecht, the Netherlands and Leiden University Medical Center ; Leiden , the Netherlands.
b The Scripps Research Institute ; La Jolla , CA USA.
MAbs. 2015;7(6):981-8. doi: 10.1080/19420862.2015.1089707. Epub 2015 Sep 30.
Antibody Engineering & Therapeutics, the annual meeting of The Antibody Society, will be held in San Diego, CA in early December 2015. In this meeting preview, the chairs provide their thoughts on the importance of their session topics, which include antibody effector functions, reproducibility of research and diagnostic antibodies, new developments in antibody-drug conjugates (ADCs), preclinical and clinical ADC data, new technologies and applications for bispecific antibodies, antibody therapeutics for non-cancer and orphan indications, antibodies to harness the cellular immune system, overcoming resistance to clinical immunotherapy, and building comprehensive IGVH-gene repertoires through discovering, confirming and cataloging new germline IGVH genes. The Antibody Society's special session will focus on "Antibodies to watch" in 2016, which are a subset of the nearly 50 antibodies currently in Phase 3 clinical studies. Featuring over 100 speakers in total, the meeting will commence with keynote presentations by Erica Ollmann Saphire (The Scripps Research Institute), Wayne A. Marasco (Dana-Farber Cancer Institute/Harvard Medical School), Joe W. Gray (Oregon Health & Science University), and Anna M. Wu (University of California Los Angeles), and it will conclude with workshops on the promise and challenges of using next-generation sequencing for antibody discovery and engineering from synthetic and in vivo libraries and on computational antibody design.
《抗体工程与治疗学》是抗体协会的年度会议,将于2015年12月初在加利福尼亚州圣地亚哥举行。在本次会议预览中,会议主席阐述了他们对各自会议主题重要性的看法,这些主题包括抗体效应功能、研究和诊断抗体的可重复性、抗体药物偶联物(ADC)的新进展、临床前和临床ADC数据、双特异性抗体的新技术和应用、非癌症及罕见病适应症的抗体治疗、利用细胞免疫系统的抗体、克服临床免疫疗法的耐药性以及通过发现、确认和编目新的种系IGVH基因构建全面的IGVH基因库。抗体协会的特别会议将聚焦2016年“值得关注的抗体”,这些抗体是目前近50种处于3期临床研究的抗体的一部分。会议共有100多位演讲者,将由埃丽卡·奥尔曼·萨菲尔(斯克里普斯研究所)、韦恩·A·马拉斯科(达纳-法伯癌症研究所/哈佛医学院)、乔·W·格雷(俄勒冈健康与科学大学)和安娜·M·吴(加利福尼亚大学洛杉矶分校)进行主题演讲开幕,并以关于利用下一代测序从合成和体内文库进行抗体发现和工程以及计算抗体设计的前景与挑战的研讨会闭幕。