Soundravally Rajendiran, Sherin Jacob, Agieshkumar Balakrishna Pillai, Daisy Mariya Samadanam, Cleetus Cherupanakkal, Narayanan Parameswaran, Kadhiravan Tamilarasu, Sujatha Sistla, Harichandrakumar Kottyen Thazhath
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, IN.
School of Chemical and Biotechnology, SASTRA University, Thanjavur, TamilNadu, IN.
Rev Inst Med Trop Sao Paulo. 2015 Jul-Aug;57(4):315-20. doi: 10.1590/S0036-46652015000400007.
The role of trace elements in dengue virulence is not yet known. The present study assessed the serum levels of two micronutrients, copper and iron, in cases of dengue fever. The study involved 96 patients of whom 48 had either severe or non-severe forms of dengue (with and without warning signs), and the remaining 48 were patients with other febrile illnesses (OFI), used as controls. Serum levels of copper and iron were evaluated at admission and by the time of defervescence using commercially available kits. At admission, no difference in the level of serum copper was observed between cases and controls. In the group of dengue cases, the copper level was found to be significantly decreased in severe and non-severe cases with warning signs, compared to non-severe cases without warning signs. In contrast, by the time of defervescence the copper level was found to be increased in all dengue cases compared to OFI controls, but no difference was observed among dengue cases. Unlike OFI controls, dengue cases showed an increasing pattern of copper levels from admission until defervescence. On the other hand, no such significant differences were observed in the serum level of iron in the clinical groups, except for a decreased iron level found in severe cases, compared to non-severe dengue without warning signs. The results show that copper is associated with dengue severity and this finding emphasizes the need to investigate the involvement of trace elements in disease severity so as to improve the prognosis of dengue.
微量元素在登革病毒毒力中的作用尚不清楚。本研究评估了登革热患者血清中两种微量营养素铜和铁的水平。该研究纳入了96名患者，其中48名患有严重或非严重形式的登革热（有或无警示体征），其余48名是患有其他发热性疾病（OFI）的患者，作为对照。使用市售试剂盒在入院时和退热时评估血清铜和铁的水平。入院时，病例组和对照组的血清铜水平无差异。在登革热病例组中，与无警示体征的非严重病例相比，有警示体征的严重和非严重病例的铜水平显著降低。相比之下，退热时，与OFI对照组相比，所有登革热病例的铜水平均升高，但登革热病例之间未观察到差异。与OFI对照组不同，登革热病例从入院到退热期间铜水平呈上升趋势。另一方面，临床组血清铁水平未观察到此类显著差异，只是与无警示体征的非严重登革热病例相比，严重病例的铁水平降低。结果表明，铜与登革热严重程度相关，这一发现强调了研究微量元素在疾病严重程度中的作用以改善登革热预后的必要性。
