Asemota Enosakhare A, Okafor Ifeyinwa M, Okoroiwu Henshaw U, Ekong Ewaro R, Anyanwu Stanley Obialor, Efiong Esienanwan Esien, Udomah Francis
Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria.
Department of Biochemistry, Federal University Lafia, Nasarawa, Nigeria.
Integr Med Res. 2018 Mar;7(1):53-60. doi: 10.1016/j.imr.2018.01.008. Epub 2018 Feb 13.
Low concentration of trace elements has been associated with poor prognosis and mortality in HIV infection.
A cross sectional study was conducted among 100 HIV-infected subjects (70 were on ART treatment, while 30 were ART naïve). Fifty (50) apparently healthy controls were enrolled. Concentration of serum levels of zinc and copper was done using atomic absorption spectrometric method, while complete blood count was determined using automated blood analyzer. CD4 T-cell count was done using cyflow cytometer.
The aim of this study was to investigate the level of some trace elements and some hematological parameters of HIV-seropositive subjects attending University of Calabar Teaching Hospital Clinic as well as prevalence of trace elements deficiency and anemic status and compare same with HIV-seronegative control.
Mean serum zinc, CD4 T-cell count, Hb, PCV, RBC, MXD, were significantly ( < 0.05) reduced in the HIV-infected subjects, while copper/zinc ratio, MCV, MCH and platelet count were significantly ( < 0.05) raised in the HIV-infected subjects. The serum Cu level was comparable ( > 0.05) with the control. ART treatment had no effect on all the parameters assessed except CD4 T-cell count. Twenty five percent (25%), 3% and 56% of the HIV-infected subjects were zinc deficient, copper deficient and anemic, respectively. Gender was found as a predictor of zinc deficiency. Copper and zinc showed weak positive correlation with CD4 T-cell count.
ART treatment did not complement zinc status in HIV infection while improving CD4 T-cell count, hence the need to consider supplementation.
微量元素浓度低与HIV感染的不良预后和死亡率相关。
对100名HIV感染者进行了一项横断面研究（70人接受抗逆转录病毒治疗，30人未接受抗逆转录病毒治疗）。招募了50名明显健康的对照者。采用原子吸收光谱法测定血清锌和铜水平，使用自动血液分析仪测定全血细胞计数。使用流式细胞仪进行CD4 T细胞计数。
本研究的目的是调查在卡拉巴尔大学教学医院诊所就诊的HIV血清阳性患者的一些微量元素水平和一些血液学参数，以及微量元素缺乏和贫血状况的患病率，并与HIV血清阴性对照者进行比较。
HIV感染者的血清锌、CD4 T细胞计数、血红蛋白、红细胞压积、红细胞计数、平均血小板体积显著降低（P<0.05），而HIV感染者的铜/锌比值、平均红细胞体积、平均红细胞血红蛋白含量和血小板计数显著升高（P<0.05）。血清铜水平与对照组相当（P>0.05）。除CD4 T细胞计数外，抗逆转录病毒治疗对所有评估参数均无影响。分别有25%、3%和56%的HIV感染者存在锌缺乏、铜缺乏和贫血。性别是锌缺乏的一个预测因素。铜和锌与CD4 T细胞计数呈弱正相关。
抗逆转录病毒治疗在改善CD4 T细胞计数的同时，并未补充HIV感染患者的锌状态，因此需要考虑补充锌。
