Gorzilio Daniela Moré, Garrido Elisa, Gaspardo Cláudia Maria, Martinez Francisco Eulogio, Linhares Maria Beatriz Martins
Faculty of Philosophy, Sciences and Letters, University of São Paulo, Avenida Bandeirantes, 3900, Ribeirão Preto, SP CEP: 14040-901, Brazil; Hospital of Clinics, Ribeirão Preto Medical School, University of São Paulo, Campus Universitário s/n, Ribeirão Preto, SP CEP: 14048-900, Brazil.
Ribeirão Preto Medical School, University of São Paulo, Avenida Tenente Catão Roxo, 2260, Ribeirão Preto, SP CEP: 14051-140, Brazil.
Early Hum Dev. 2015 Dec;91(12):769-75. doi: 10.1016/j.earlhumdev.2015.09.003. Epub 2015 Sep 28.
Neonatal Intensive Care Units (NICUs) protect preterm infants; otherwise, this is a stressful environment including painful stimuli.
To compare early neurobehavioral development prior to term-age in preterm infants at 34-36weeks of post-conceptional age in different gestational ages, and to examine the effects of prematurity level and acute stressful events during NICU hospitalization on neurobehavioral development.
Cross-sectional design.
Forth-five preterm infants, 34-36weeks of post-conceptional age, were distributed into groups: extreme preterm (EPT; 23-28weeks of gestational age; n=10), moderate preterm (MPT; 29-32weeks of gestational age; n=10), late preterm (LPT; 34-36weeks of gestational age; n=25).
All of the neonates were evaluated using the Neurobehavioral Assessment of Preterm Infant (NAPI) prior to 37weeks of post-conceptional age. The Neonatal Infant Stressor Scale (NISS) was applied for EPT and MPT infants during NICU hospitalization, and medical charts were analyzed.
The EPT group experienced significantly more acute stressful events during NICU hospitalization than the MPT group. The MPT group had lower scores in motor development and vigor than the EPT and LPT group, and they exhibited poorer quality crying than the LPT group. Motor development and vigor and alertness and orientation in preterm infants were predicted by prematurity level and acute stressful events.
The extreme preterm was exposed to higher stressful experiences than moderate and late preterm infants. However, the moderate preterm infants presented more vulnerable than the other counterparts in motor and vigor outcomes.
新生儿重症监护病房（NICU）保护早产儿；否则，这是一个充满压力的环境，包括疼痛刺激。
比较孕龄34 - 36周的不同胎龄早产儿足月前的早期神经行为发育情况，并研究NICU住院住院期间早产程度和急性应激事件对神经行为发育的影响。
横断面设计。
45名孕龄34 - 36周的早产儿被分为以下几组：极早早产儿（EPT；胎龄23 - 28周；n = 10），中度早产儿（MPT；胎龄29 - 32周；n = 10），晚期早产儿（LPT；胎龄34 - 36周；n = 25）。
所有新生儿在孕龄37周前使用早产儿神经行为评估（NAPI）进行评估。对EPT和MPT组婴儿在NICU住院期间应用新生儿应激源量表（NISS），并分析病历。
EPT组在NICU住院期间经历的急性应激事件明显多于MPT组。MPT组在运动发育和活力方面的得分低于EPT组和LPT组，且其哭声质量比LPT组差。早产儿的运动发育、活力、警觉性和定向能力可由早产程度和急性应激事件预测。
极早早产儿比中度和晚期早产儿面临更高的应激经历。然而，中度早产儿在运动和活力方面比其他早产儿表现得更脆弱。
