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发育性协调障碍:核心感觉运动缺陷、神经生物学与病因学

Developmental coordination disorder: core sensori-motor deficits, neurobiology and etiology.

作者信息

Gomez Alice, Sirigu Angela

机构信息

Centre de Neuroscience Cognitive, CNRS, UMR 5229, 67 Boulevard Pinel, 69675 Bron, France; Université Claude Bernard Lyon 1, ESPE, Lyon, France.

Centre de Neuroscience Cognitive, CNRS, UMR 5229, 67 Boulevard Pinel, 69675 Bron, France.

出版信息

Neuropsychologia. 2015 Dec;79(Pt B):272-87. doi: 10.1016/j.neuropsychologia.2015.09.032. Epub 2015 Sep 28.

Abstract

Among developmental disorders, DCD is one of the least studied and less understood one (Bishop, 2010). This review summarizes the current understanding of developmental coordination disorder in neuropsychology with a focus mainly on high level sensorimotor impairments, its etiology and its neural bases. We summarize these core deficits in the framework of an influent motor control model (Blakemore et al., 2002). DCD has several environmental risk factors which probably interplay with genetic factors but those have not been sufficiently identified. High-level sensori-motor deficits are probably multifactorial in DCD and involve predictive coding deficits as well as weaknesses in perceptual and sensory integration. At the brain level, DCD is associated with impaired structure and functions within the motor network. Throughout the review we highlight exciting new findings as well as potential future lines of research to provide a more comprehensive understanding of this disorder.

摘要

在发育障碍中,发育性协调障碍是研究最少且了解较少的疾病之一(毕晓普,2010年)。本综述总结了神经心理学领域目前对发育性协调障碍的理解,主要聚焦于高级感觉运动障碍、其病因及神经基础。我们在一个有影响力的运动控制模型框架内(布莱克莫尔等人,2002年)总结了这些核心缺陷。发育性协调障碍有多种环境风险因素,可能与遗传因素相互作用,但尚未得到充分确认。高级感觉运动缺陷在发育性协调障碍中可能是多因素的,涉及预测编码缺陷以及感知和感觉整合方面的弱点。在大脑层面,发育性协调障碍与运动网络内结构和功能受损有关。在整个综述中,我们突出了令人兴奋的新发现以及未来潜在的研究方向,以便更全面地理解这种疾病。

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