Farmer Marie, Echenne Bernard, Drouin Regen, Bentourkia M'hamed
Department of Nuclear Medicine and Radiobiology, 3001, 12th Avenue North, Sherbrooke (Qc) J1H 5N4. Canada.
Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine, Laval University, 2705 Bd Laurier, Quebec City, G1V 4G2. Canada.
Curr Pediatr Rev. 2017;13(2):111-119. doi: 10.2174/1573396313666170726113550.
Developmental Coordination Disorder (DCD) is a neurological impairment occurring in nearly 6% of general population, and sometimes mimics other developmental disorders like Attention Deficit Hyperactivity Disorder (ADHD) or, in the most severe cases, intellectual deficiency.
To review the general portrait of DCD, the physiology, the clinical assessments, and to provide an overview of functional studies on the subject. We finally report some proposed DCD managements which vary depending on the manifestation of the disorder and on the goals of the therapy.
DCD can be stated as a sum of fine motor, perceptual visual and executive difficulties, emerging during childhood brain development and lasting throughout adulthood. Even if DCD can be isolated from other co-morbidities in certain individuals, it is still difficult to categorize it in delimited subclasses of characteristics, e.g. problems of vision or language. The findings in functional imaging also diverge in locating the cerebral deficit for a given motor task.
Finding a single explanation seems difficult as many cerebral regions are associated with DCD and many clinical aspects are involved, but, further studies could explore genetic (or epigenetic) explanation for the prevalence of DCD in population.
发育性协调障碍(DCD)是一种神经功能障碍,在普通人群中的发生率近6%,有时会与其他发育障碍相似,如注意力缺陷多动障碍(ADHD),在最严重的情况下,还会出现智力缺陷。
综述DCD的总体情况、生理学、临床评估,并概述该主题的功能研究。我们最后报告了一些针对DCD的管理建议,这些建议因疾病表现和治疗目标而异。
DCD可表现为精细运动、视觉感知和执行功能方面的困难,这些困难在儿童大脑发育过程中出现,并持续至成年。即使在某些个体中DCD可以与其他共病相区分,但仍难以将其归类为具有明确特征的子类,例如视觉或语言问题。功能成像的研究结果在确定特定运动任务的脑功能缺陷位置方面也存在分歧。
由于许多脑区与DCD相关且涉及许多临床方面,因此找到单一的解释似乎很困难,但是,进一步的研究可以探索DCD在人群中普遍存在的遗传(或表观遗传)解释。