病毒群体通过囊泡进行细胞间传播。
Intercellular Transmission of Viral Populations with Vesicles.
作者信息
Altan-Bonnet Nihal, Chen Ying-Han
机构信息
Laboratory of Host-Pathogen Dynamics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Laboratory of Host-Pathogen Dynamics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
J Virol. 2015 Dec;89(24):12242-4. doi: 10.1128/JVI.01452-15. Epub 2015 Sep 30.
Abstract
A common paradigm holds that during cell-to-cell transmission, viruses behave as lone soldiers. Recently, we discovered not only that enteroviruses are transmitted via vesicles as populations of viral particles but also that this type of transmission enhances their infection efficiency (Y. H. Chen et al., Cell 160: 619-630, 2015). This mechanism could be advantageous for the overall fitness of the viral population, promoting genetic interplay by enabling viral quasispecies to collectively infect a susceptible host cell. Here, we discuss these findings in the context of viral pathogenesis and also propose that this novel type of vesicular transmission is widespread among different virus families and includes populations of both viral particles and naked viral genomes.
摘要
一种常见的模式认为，在细胞间传播过程中，病毒的行为就像单兵作战的士兵。最近，我们不仅发现肠道病毒通过囊泡以病毒粒子群体的形式进行传播，而且这种传播方式还提高了它们的感染效率（Y. H. 陈等人，《细胞》160: 619 - 630，2015年）。这种机制可能对病毒群体的整体适应性有利，通过使病毒准种能够共同感染易感宿主细胞来促进基因相互作用。在这里，我们在病毒发病机制的背景下讨论这些发现，并提出这种新型的囊泡传播在不同病毒家族中广泛存在，并且包括病毒粒子群体和裸露的病毒基因组。
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