Wang Peng, Zhi Hui, Zhang Yunpeng, Liu Yue, Zhang Jizhou, Gao Yue, Guo Maoni, Ning Shangwei, Li Xia
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China
Database (Oxford). 2015 Sep 30;2015. doi: 10.1093/database/bav098. Print 2015.
In this study, we describe miRSponge, a manually curated database, which aims at providing an experimentally supported resource for microRNA (miRNA) sponges. Recent evidence suggests that miRNAs are themselves regulated by competing endogenous RNAs (ceRNAs) or 'miRNA sponges' that contain miRNA binding sites. These competitive molecules can sequester miRNAs to prevent them interacting with their natural targets to play critical roles in various biological and pathological processes. It has become increasingly important to develop a high quality database to record and store ceRNA data to support future studies. To this end, we have established the experimentally supported miRSponge database that contains data on 599 miRNA-sponge interactions and 463 ceRNA relationships from 11 species following manual curating from nearly 1200 published articles. Database classes include endogenously generated molecules including coding genes, pseudogenes, long non-coding RNAs and circular RNAs, along with exogenously introduced molecules including viral RNAs and artificial engineered sponges. Approximately 70% of the interactions were identified experimentally in disease states. miRSponge provides a user-friendly interface for convenient browsing, retrieval and downloading of dataset. A submission page is also included to allow researchers to submit newly validated miRNA sponge data. Database URL: http://www.bio-bigdata.net/miRSponge.
在本研究中，我们描述了miRSponge，这是一个人工整理的数据库，旨在为微小RNA（miRNA）海绵提供实验支持的资源。最近的证据表明，miRNA本身受竞争性内源性RNA（ceRNA）或含有miRNA结合位点的“miRNA海绵”调控。这些竞争性分子可以隔离miRNA，防止它们与其天然靶标相互作用，从而在各种生物和病理过程中发挥关键作用。开发一个高质量的数据库来记录和存储ceRNA数据以支持未来的研究变得越来越重要。为此，我们建立了实验支持的miRSponge数据库，该数据库在对近1200篇已发表文章进行人工整理后，包含了来自11个物种的599个miRNA-海绵相互作用和463个ceRNA关系的数据。数据库类别包括内源性产生的分子，如编码基因、假基因、长链非编码RNA和环状RNA，以及外源性引入的分子，如病毒RNA和人工工程海绵。大约70%的相互作用是在疾病状态下通过实验确定的。miRSponge提供了一个用户友好的界面，方便浏览、检索和下载数据集。还包括一个提交页面，允许研究人员提交新验证的miRNA海绵数据。数据库网址：http://www.bio-bigdata.net/miRSponge 。
