Healy Jane A, Dave Sandeep S
Department of Hematology/Oncology, Duke University, DUMC Box 3841, Durham, NC, 27710, USA.
Center for Genomic and Computational Biology, Duke University, CIEMAS, 2177C, 101 Science Drive, Box 3382, Durham, NC, 27708, USA.
Curr Top Microbiol Immunol. 2015;390(Pt 1):315-37. doi: 10.1007/978-3-319-22822-8_13.
Epstein-Barr virus (EBV) infection is a common feature of B cell lymphoproliferative disorders (LPDs), including diffuse large B cell lymphoma. Approximately 10 % of DLBCLs are EBV-positive, with the highest incidence in immunocompromised and elderly patients. Here, we review the clinical, genetic, and pathologic characteristics of DLBCL and discuss the molecular role of EBV in lymphoma tumorigenesis. Using EBV-positive DLBCL of the elderly as a model, we describe the key features of EBV-positive DLBCL. Studies of EBV-positive DLBCL of the elderly demonstrate that EBV-positive DLBCL has a distinct biology, related to both viral and host factors. The pathogenic mechanisms noted in EBV-positive DLBCL of the elderly, including enhanced NFκB activity, are likely to be a generalizable feature of EBV-positive DLBCL. Therefore, we review how this information might be used to target the EBV or its host response for the development of novel treatment strategies.
爱泼斯坦-巴尔病毒（EBV）感染是B细胞淋巴增殖性疾病（LPDs）的一个常见特征，包括弥漫性大B细胞淋巴瘤。大约10%的弥漫性大B细胞淋巴瘤是EBV阳性，在免疫功能低下和老年患者中发病率最高。在此，我们回顾弥漫性大B细胞淋巴瘤的临床、遗传和病理特征，并讨论EBV在淋巴瘤肿瘤发生中的分子作用。以老年EBV阳性弥漫性大B细胞淋巴瘤为模型，我们描述了EBV阳性弥漫性大B细胞淋巴瘤的关键特征。对老年EBV阳性弥漫性大B细胞淋巴瘤的研究表明，EBV阳性弥漫性大B细胞淋巴瘤具有独特的生物学特性，这与病毒和宿主因素均有关。在老年EBV阳性弥漫性大B细胞淋巴瘤中发现的致病机制，包括增强的NFκB活性，可能是EBV阳性弥漫性大B细胞淋巴瘤的一个普遍特征。因此，我们回顾如何利用这些信息来针对EBV或其宿主反应开发新的治疗策略。
