Gelb D J, Lowenstein D H, Aminoff M J
Department of Neurology, University of California, San Francisco 94143.
Neurology. 1989 Jan;39(1):80-4. doi: 10.1212/wnl.39.1.80.
We administered local injections of botulinum toxin to 20 patients with torticollis in a blinded, placebo-controlled study. Each patient received four sets of injections: three different doses of botulinum toxin and one placebo. The order of the sessions was random and unknown to the patients. Sixteen of the patients (80%) reported subjective improvement to at least one dose of botulinum toxin; 11 (55%) reported substantial improvement. No objective benefit was documented. Side effects were minor and transient, although dysphagia occurred in four. Some patients reported that the effect waned despite persistent relaxation or even flaccidity of previously overactive muscles, suggesting a change in the pattern of muscle activity after botulinum toxin injections.
在一项双盲、安慰剂对照研究中，我们对20名斜颈患者进行了肉毒杆菌毒素局部注射。每位患者接受四组注射：三种不同剂量的肉毒杆菌毒素和一组安慰剂。注射疗程的顺序是随机的，患者并不知晓。16名患者（80%）报告至少对一剂肉毒杆菌毒素有主观改善；11名患者（55%）报告有显著改善。未记录到客观益处。副作用轻微且短暂，尽管有4名患者出现吞咽困难。一些患者报告，尽管先前过度活跃的肌肉持续松弛甚至出现弛缓，但效果仍逐渐减弱，这表明肉毒杆菌毒素注射后肌肉活动模式发生了变化。
