肉毒杆菌毒素治疗痉挛性斜颈。
Botulinum toxin treatment in spasmodic torticollis.
作者信息
Blackie J D, Lees A J
机构信息
National Hospital for Nervous Diseases, London.
出版信息
J Neurol Neurosurg Psychiatry. 1990 Aug;53(8):640-3. doi: 10.1136/jnnp.53.8.640.
Botulinum toxin A was administered to 19 patients in a double-blind placebo controlled trial. Toxin was more effective than placebo for improving both head position and pain which was measured by an objective rating scale and videofilm assessments. Following the controlled trial, treatment with botulinum toxin was continued in an open fashion. A total of 60 patients with torticollis received toxin in a total of 117 treatment periods. The mean follow up period was 8.4 months. In 39 patients with pain there was benefit in 77% of treatment periods. Some improvement in neck posture occurred in 83% of the treatment periods with a mean duration of 12 weeks. Side effects were frequent with dysphagia being the most common (28% of treatment periods). Botulinum toxin is an effective treatment for toticollis but treatment should be initiated with doses at the lower end of the range used in this study (400-600 mouse units).
在一项双盲安慰剂对照试验中，对19名患者施用了A型肉毒杆菌毒素。通过客观评分量表和视频影片评估测量，毒素在改善头部位置和疼痛方面比安慰剂更有效。在对照试验之后，以开放方式继续用肉毒杆菌毒素进行治疗。共有60名斜颈患者在总共117个治疗周期中接受了毒素治疗。平均随访期为8.4个月。在39名有疼痛的患者中，77%的治疗周期有疗效。83%的治疗周期颈部姿势有一些改善，平均持续时间为12周。副作用很常见，吞咽困难最为常见（占治疗周期的28%）。肉毒杆菌毒素是治疗斜颈的有效方法，但治疗应从本研究中使用范围的较低端剂量（400 - 600鼠单位）开始。
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