Sá Joceline C F, Costa Eduardo C, da Silva Ester, Tamburús Nayara Y, Porta Alberto, Medeiros Leany F, Lemos Telma M A M, Soares Elvira M M, Azevedo George D
Post-Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Post-Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Department of Physical Education, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Int J Cardiol. 2016 Jan 1;202:356-61. doi: 10.1016/j.ijcard.2015.09.031. Epub 2015 Sep 25.
This study aimed to evaluate the effects of aerobic exercise on cardiac autonomic modulation in women with polycystic ovary syndrome (PCOS).
Thirty women with PCOS (25.8±4.8 years old; body mass index, BMI≥25 kg/m2) were divided into two groups; exercise group (n=15) and control group (n=15). R-R interval was recorded during 15-min at rest in the supine position. Heart rate variability (HRV) was analyzed by linear (rMSSD, SDNN, LF, HF, LFnu, HFnu, and LF/HF) and nonlinear methods (Shannon entropy, SE; symbolic analyses, 0 V%, 1 V%, 2LV%, and 2UV%) at baseline and after 16 weeks. The multivariate analysis of covariance was used to analyze the effects of exercise on HRV indexes, adjusted for changes in BMI, fasting insulin, and testosterone level.
The exercise group increased parasympathetic modulation (rMSSD, HF, HFnu, 2UV%; (p<0.05)) and decreased sympathetic modulation (LF, LFnu, 0 V%; (p<0.05)) independently of changes in BMI, fasting insulin, and testosterone level. Moreover, the exercise group decreased resting HR and systolic blood pressure (p<0.05). All parameters remained unchanged in the control group.
Aerobic exercise increased vagal modulation and decreased sympathetic modulation in women with PCOS. This finding reinforces the recommendations for exercise during the clinical management of these patients.
本研究旨在评估有氧运动对多囊卵巢综合征（PCOS）女性心脏自主神经调节的影响。
30名PCOS女性（年龄25.8±4.8岁；体重指数，BMI≥25kg/m²）被分为两组；运动组（n=15）和对照组（n=15）。记录仰卧位休息15分钟时的R-R间期。在基线和16周后，通过线性（rMSSD、SDNN、LF、HF、LFnu、HFnu和LF/HF）和非线性方法（香农熵，SE；符号分析，0V%、1V%、2LV%和2UV%）分析心率变异性（HRV）。采用协方差多元分析来分析运动对HRV指标的影响，并对BMI、空腹胰岛素和睾酮水平的变化进行校正。
运动组独立于BMI、空腹胰岛素和睾酮水平的变化，增加了副交感神经调节（rMSSD、HF、HFnu、2UV%；（p<0.05）），并降低了交感神经调节（LF、LFnu、0V%；（p<0.05））。此外，运动组降低了静息心率和收缩压（p<0.05）。对照组所有参数均保持不变。
有氧运动增加了PCOS女性的迷走神经调节并降低了交感神经调节。这一发现强化了在这些患者临床管理期间进行运动的建议。
