用于精准医学应用的活微滤循环肿瘤细胞（CTC）的热响应释放。
Thermoresponsive release of viable microfiltrated Circulating Tumor Cells (CTCs) for precision medicine applications.
作者信息
Ao Zheng, Parasido Erika, Rawal Siddarth, Williams Anthony, Schlegel Richard, Liu Stephen, Albanese Chris, Cote Richard J, Agarwal Ashutosh, Datar Ram H
机构信息
Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Departments of Oncology and Pathology, and the Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, USA.
出版信息
Lab Chip. 2015 Nov 21;15(22):4277-82. doi: 10.1039/c5lc01024a.
Abstract
Stimulus responsive release of Circulating Tumor Cells (CTCs), with high recovery rates from their capture platform, is highly desirable for off-chip analyses. Here, we present a temperature responsive polymer coating method to achieve both release as well as culture of viable CTCs captured from patient blood samples.
摘要
对于芯片外分析而言，能从捕获平台实现高回收率的循环肿瘤细胞（CTC）的刺激响应释放是非常理想的。在此，我们提出一种温度响应性聚合物涂层方法，以实现从患者血样中捕获的活CTC的释放及培养。
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