Maurer Marcus, Church Martin K, Metz Martin, Starkhammar Maria, Hamsten Carl, van Hage Marianne
Department of Dermatology and Allergy, Allergie-Centrum-Charitx00E9;, Charitx00E9; - Universitx00E4;tsmedizin Berlin, Berlin, Germany.
Int Arch Allergy Immunol. 2015;167(4):250-2. doi: 10.1159/000440653. Epub 2015 Oct 2.
Tick bite-induced galactose-α-1,3-galactose (α-Gal) IgE and subsequent ingestion of red meat may cause delayed severe allergic reactions including urticaria, gastrointestinal symptoms or anaphylaxis. We tested the hypothesis that increased levels of IgE to α-Gal due to tick bites and the subsequent ingestion of red meat or meat products may possibly be an un(der)recognized cause of chronic spontaneous urticaria (CSU).
Levels of IgE to α-Gal and total IgE were measured (ImmunoCAP, Phadia AB/Thermo Fisher Scientific) in 83 patients (61 female and 22 male, median age 43 years, range 18-82) from the Department of Dermatology and Allergy, Charité - Universitätsmedizin, Berlin, Germany. All had been clinically diagnosed with moderate-to-severe CSU of a median duration of 2.9 years (range 0.1-50).
Eighty of the 83 patients (96%) had undetectable (<0.1 kUA/l) serum levels of IgE against α-Gal. The levels in the remaining 3 were all low (0.25, 0.4 and 3.1 kUA/l). In no patient, including those with measurable serum levels of IgE against α-Gal, was eating red meat associated with the development of symptoms of urticaria.
Our results indicate that an allergic response to α-Gal is highly unlikely to be a hitherto unrecognized common cause of CSU.
蜱虫叮咬诱导产生的抗半乳糖-α-1,3-半乳糖（α-Gal）IgE以及随后摄入红肉可能会引发包括荨麻疹、胃肠道症状或过敏反应在内的迟发性严重过敏反应。我们检验了这样一种假设，即蜱虫叮咬以及随后摄入红肉或肉制品导致的抗α-Gal IgE水平升高可能是慢性自发性荨麻疹（CSU）一个未（被）认识到的病因。
对来自德国柏林夏里特大学医学中心皮肤科与过敏科的83例患者（61例女性，22例男性，年龄中位数43岁，范围18 - 82岁）检测了抗α-Gal IgE和总IgE水平（免疫化学发光法，Phadia AB/赛默飞世尔科技公司）。所有患者临床诊断为中度至重度CSU, 病程中位数为2.9年（范围0.1 - 50年）。
83例患者中有80例（96%）血清抗α-Gal IgE水平检测不到（<0.1 kUA/l）。其余3例的水平均较低（0.25、0.4和3.1 kUA/l）。包括抗α-Gal IgE血清水平可测者在内，没有患者食用红肉后出现荨麻疹症状。
我们的结果表明，对α-Gal的过敏反应极不可能是CSU此前未被认识到的常见病因。
