Relationship between the Level of Circulating Endothelial Micro-Particles in the Blood and Blood Lipid Content in Uyghur and Han Patients with Acute Coronary Syndrome.

BACKGROUND

The aim of this study was to analyze the relationships between the endothelial cell micro-particles (EMPs) blood level and the blood lipid in Uygur and Han patients with acute coronary syndrome (ACS) in order to provide a theoretical basis for the pathogenesis study of ACS.

METHODS

100 ACS patients (50 cases for each ethnic group) were selected as the patient group from January 2012 to August 2013 from the Cardiology Sector of the People's Hospital of the Xinjiang Uygur Autonomous Region, and 100 healthy subjects (50 cases for each ethnic group) were selected as the control group. Blood samples were collected. Flow cytometry was used to detect the EMP levels. An automatic biochemical analyzer was used to detect the levels of the blood lipids and the related indicators.

RESULTS

The EMP levels in the patient group of both ethnicities were higher than those in the control group (p < 0.05), although no statistically significant differences were found in the EMP levels between Uygur and Han in the patient groups, nor in the control group (p > 0.05). Multiple linear regression analysis showed significant correlations between the EMP levels and the blood lipid related indexes (p < 0.05), with a degree of correlation of 86.70%. Path analysis indicated that the EMP level was mainly affected by high density lipoprotein cholesterol (HDL-C) (p < 0.05).

CONCLUSIONS

The EMP level in the blood of ACS patients is significantly higher than in the control group, and the levels between HDL-C and EMPs are negatively correlated. The pathogenesis of ACS could be associated with the increase of the EMP level in the blood, and HDL-C might affect the level of circulating EMPs.