Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Students' Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int J Biol Macromol. 2018 May;111:696-705. doi: 10.1016/j.ijbiomac.2018.01.061. Epub 2018 Jan 12.
The main aim of the present study was to design pH-sensitive nanocomposite hydrogel beads, based on carboxymethyl cellulose (CMC) and montmorillonite (Mt)-propranolol (PPN) nanohybrid, and evaluate whether the prepared nanocomposite beads could potentially be used as oral drug delivery systems. PPN-as a model drug-was intercalated into the interlayer space of Mt clay mineral via the ion exchange procedure. The resultant nanohybrid (Mt-PPN) was applied to fabricate nanocomposite hydrogel beads by association with carboxymethyl cellulose. The characterization of test samples was performed using different techniques: X-Ray Diffraction (XRD), IR spectroscopy (FT-IR), thermal gravity analysis (TGA), and scanning electron microscopy (SEM). The drug encapsulation efficiency was evaluated by UV-vis spectroscopy, and was found to be high for Mt/CMC beads. In vitro drug release test was performed in the simulated gastrointestinal conditions to evaluate the efficiency of Mt-PPN/CMC nanocomposite beads as a controlled-release drug carrier. The drug release profiles indicated that the Mt-PPN/CMC nanocomposite beads had high stability against stomach acid and a sustained- and controlled-release profile for PPN under the simulated intestinal conditions.
本研究的主要目的是设计基于羧甲基纤维素（CMC）和蒙脱土（Mt）-普萘洛尔（PPN）纳米复合物的 pH 敏感纳米复合水凝胶珠，并评估所制备的纳米复合珠是否可潜在用作口服药物递送系统。PPN 作为模型药物通过离子交换过程被插入 Mt 粘土矿物的层间空间。所得纳米复合物（Mt-PPN）通过与羧甲基纤维素结合来用于制备纳米复合水凝胶珠。使用不同的技术对测试样品进行了表征：X 射线衍射（XRD），红外光谱（FT-IR），热重分析（TGA）和扫描电子显微镜（SEM）。通过紫外可见光谱评估了药物包封效率，发现 Mt/CMC 珠的包封效率很高。在模拟胃肠道条件下进行了体外药物释放试验，以评估 Mt-PPN/CMC 纳米复合珠作为控制释放药物载体的效率。药物释放曲线表明，Mt-PPN/CMC 纳米复合珠在模拟肠条件下对胃酸具有高稳定性，并且对 PPN 具有持续和控制释放的特性。
