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人伏隔核的动态风险控制

Dynamic risk control by human nucleus accumbens.

作者信息

Nachev Parashkev, Lopez-Sosa Fernando, Gonzalez-Rosa Javier Jesus, Galarza Ana, Avecillas Josue, Pineda-Pardo Jose Angel, Lopez-Ibor Juan José, Reneses Blanca, Barcia Juan Antonio, Strange Bryan

机构信息

1 Institute of Neurology, UCL, London, UK

2 Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Technical University of Madrid, Spain.

出版信息

Brain. 2015 Dec;138(Pt 12):3496-502. doi: 10.1093/brain/awv285. Epub 2015 Oct 1.

DOI:10.1093/brain/awv285
PMID:26428667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4655342/
Abstract

Real-world decisions about reward often involve a complex counterbalance of risk and value. Although the nucleus accumbens has been implicated in the underlying neural substrate, its criticality to human behaviour remains an open question, best addressed with interventional methodology that probes the behavioural consequences of focal neural modulation. Combining a psychometric index of risky decision-making with transient electrical modulation of the nucleus accumbens, here we reveal profound, highly dynamic alteration of the relation between probability of reward and choice during therapeutic deep brain stimulation in four patients with treatment-resistant psychiatric disease. Short-lived phasic electrical stimulation of the region of the nucleus accumbens dynamically altered risk behaviour, transiently shifting the psychometric function towards more risky decisions only for the duration of stimulation. A critical, on-line role of human nucleus accumbens in dynamic risk control is thereby established.

摘要

现实世界中关于奖励的决策往往涉及风险与价值之间复杂的权衡。尽管伏隔核被认为与潜在的神经基质有关，但其对人类行为的关键性仍是一个悬而未决的问题，最好通过探究局部神经调节行为后果的干预方法来解决。我们将风险决策的心理测量指标与伏隔核的短暂电调制相结合，在此揭示了4例难治性精神疾病患者在治疗性脑深部刺激期间奖励概率与选择之间关系的深刻、高度动态的变化。伏隔核区域的短暂阶段性电刺激动态改变了风险行为，仅在刺激持续期间将心理测量函数暂时转向更具风险的决策。由此确立了人类伏隔核在动态风险控制中的关键在线作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff1/4655342/87eecdda92b0/awv285f4p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff1/4655342/36b4aca1fcbc/awv285fig1g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff1/4655342/d502238e9340/awv285f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff1/4655342/38d643156ada/awv285f2p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff1/4655342/98be45c073fe/awv285f3p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff1/4655342/87eecdda92b0/awv285f4p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff1/4655342/36b4aca1fcbc/awv285fig1g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff1/4655342/d502238e9340/awv285f1p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff1/4655342/38d643156ada/awv285f2p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff1/4655342/98be45c073fe/awv285f3p.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ff1/4655342/87eecdda92b0/awv285f4p.jpg

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