Entezari Mohammad Hassan
Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
J Educ Health Promot. 2015 Aug 6;4:67. doi: 10.4103/2277-9531.162388. eCollection 2015.
Cardiovascular disease is the major cause of mortality in developed countries and has an increasing trend in developing countries. There are some evidences that calcium supplementation may decrease blood pressure and consequently cardiovascular disease, but they are not conclusive and there is no agreement in this respect. The aim of the present study was to assess the effect of supplementary calcium on systolic and diastolic blood pressure in healthy adult women aged 18-30 years.
Seventy-five normotensive volunteers were randomly divided into two groups, the treatment group received 1000 mg/day calcium (four doses of 625 mg calcium carbonate) for 1 month and the control group received placebo (dextrose). Systolic and diastolic blood pressure was determined before and after intervention in supine position after 10 min of rest.
The mean daily calcium intake from food was 773.9 mg in treatment and 721 mg in control group (no significant difference) but in both the groups dietary calcium intake was less than the recommended dietary allowance: After calcium supplementation, the mean change of systolic blood pressure was not significant in the two groups, but diastolic blood pressure reduced in treatment group and increased in control group (-4.9 vs 2.6 mmHg) (P < 0.05).
These results suggest that, calcium supplementation does not have any effect on systolic blood pressure of our volunteers but can decrease diastolic blood pressure significantly and therefore it seems that calcium supplementation may be useful for people with increased diastolic blood pressure, especially for those who receive less calcium than recommended dietary allowance.
心血管疾病是发达国家的主要死因，且在发展中国家呈上升趋势。有证据表明补钙可能降低血压，进而降低心血管疾病风险，但这些证据并不确凿，在这方面也未达成共识。本研究的目的是评估补充钙对18至30岁健康成年女性收缩压和舒张压的影响。
75名血压正常的志愿者被随机分为两组，治疗组每天服用1000毫克钙（四剂625毫克碳酸钙），持续1个月，对照组服用安慰剂（葡萄糖）。在休息10分钟后，于仰卧位干预前后测定收缩压和舒张压。
治疗组食物中钙的平均每日摄入量为773.9毫克，对照组为721毫克（无显著差异），但两组的膳食钙摄入量均低于推荐膳食摄入量。补钙后，两组收缩压的平均变化不显著，但治疗组舒张压降低，对照组升高（-4.9对2.6毫米汞柱）（P<0.05）。
这些结果表明，补钙对我们志愿者的收缩压没有任何影响，但可显著降低舒张压，因此，补钙可能对舒张压升高的人群有用，尤其是那些膳食钙摄入量低于推荐膳食摄入量的人。
