Laboratory of Physics of Living Matter, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Curr Opin Cell Biol. 2015 Oct;36:113-21. doi: 10.1016/j.ceb.2015.09.001. Epub 2015 Sep 30.
Adherent cells migrate and change their shape by means of protrusion and retraction at their edges. When and where these activities occur defines the shape of the cell and the way it moves. Despite a great deal of knowledge about the structural organization, components, and biochemical reactions involved in protrusion and retraction, the origins of their spatial and temporal patterns are still poorly understood. Chemical signaling circuitry is believed to be an important source of patterning, but recent studies highlighted mechanisms based on physical forces, motion, and mechanical feedback.
贴壁细胞通过边缘的伸出和缩回进行迁移并改变形状。这些活动发生的时间和地点决定了细胞的形状及其运动方式。尽管人们对参与伸出和缩回的结构组织、成分和生化反应有了很多了解，但它们的时空模式的起源仍知之甚少。化学信号转导通路被认为是一种重要的模式形成来源，但最近的研究强调了基于物理力、运动和机械反馈的机制。
