一种合成丁烯内酯二萜现在是从马达加斯加干燥森林植物绢萼后蕊苣苔中分离出的天然产物。
A Synthetic Butenolide Diterpene is now a Natural Product Isolated from Metaporana sericosepala, a Plant from the Madagascar Dry Forest.
作者信息
Presley Christopher C, Rakotondraibe L Harinantenaina, Brodie Peggy J, Callmander Martin W, Randrianaivo Richard, Rasamison Vincent E, Rakotobe Etienne, Kingston David G I
出版信息
Nat Prod Commun. 2015 Sep;10(9):1505-7.
Antiproliferative bioassay-guided fractionation of the ethanolic extract of the endemic Madagascan plant Metaporana sericosepala led to the first natural product isolation of a butenolide diterpene, which was synthesized during an anti-inflammatory study in 1988. The structure of the compound was elucidated as 3-homofarnesyl-4-hydroxybutenolide (1) by analysis of its spectroscopic data, including 1D- and 2D-NMR data and chemical evidence. The once synthetic compound can now also be considered as a natural product. Compound 1 had modest antiproliferative activity towards the A2780 ovarian cancer cell line,with an IC50 value of 8 µM.
对马达加斯加特有植物绢萼梅塔波拉纳乙醇提取物进行抗增殖生物测定导向的分级分离，首次从天然产物中分离出一种丁烯内酯二萜，该化合物曾在1988年的一项抗炎研究中被合成。通过对其光谱数据（包括一维和二维核磁共振数据）及化学证据的分析，该化合物的结构被鉴定为3-高法呢基-4-羟基丁烯内酯（1）。这种曾经通过合成得到的化合物现在也可被视为天然产物。化合物1对A2780卵巢癌细胞系具有适度的抗增殖活性，IC50值为8 μM。
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