星状三香豆素，一种来自马达加斯加干燥森林的星状崖摩属植物的具有抗增殖作用的4'-羟基-2',3'-二氢异戊烯基化甲基香豆素。
Astrotricoumarin, an antiproliferative 4'-hydroxy-2',3'-dihydroprenylated methylcoumarin from an Astrotrichilia sp. from the Madagascar dry forest.
作者信息
Harinantenaina Liva, Brodie Peggy J, Callmander Martin W, Randrianaivo Richard, Rakotonandrasana Stephan, Rasamison Vincent E, Rakotobe Etienne, Kingston David G I
机构信息
Department of Chemistry, M/C 0212, Virginia Tech, Blacksburg, VA 24061, USA.
出版信息
Nat Prod Commun. 2011 Sep;6(9):1259-62.
Bioassay guided fractionation of the ethanol extract of a new endemic species of the genus Astrotrichilia led to the isolation of the new antiproliferative 3-(4'-hydroxy-2',3'-dihydroprenyl)-4,6-dimethoxy-5-methylcoumarin, named astrotricoumarin (8) with an IC50 value of 6.8 microM against the A2780 cell line. The structure of compound 8 was elucidated on the basis of its physical and spectroscopic data, including extensive 1D- and 2D-NMR analysis.
对一种新的星油麻属地方特有物种的乙醇提取物进行生物测定导向的分级分离，得到了新的具有抗增殖活性的3-(4'-羟基-2',3'-二氢异戊二烯基)-4,6-二甲氧基-5-甲基香豆素，命名为星油麻香豆素(8)，其对A2780细胞系的IC50值为6.8微摩尔。化合物8的结构是根据其物理和光谱数据确定的，包括广泛的一维和二维核磁共振分析。
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