海洋海绵 Hyrtios communis 中的甾体倍半萜的结构和潜在抗肿瘤活性。
Structures and potential antitumor activity of sesterterpenes from the marine sponge Hyrtios communis.
机构信息
Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA.
出版信息
J Nat Prod. 2013 Aug 23;76(8):1492-7. doi: 10.1021/np400350k. Epub 2013 Aug 14.
Abstract
The extract of marine sponge Hyrtios communis was found to inhibit activation of the transcription factor hypoxia-inducible factor-1 (HIF-1) in T47D human breast tumor cells. Bioassay-guided isolation led to the identification of six new (1-6) and five previously reported (7-11) sesterterpene analogues and two unrelated sesterterpenes. Two new sesterterpenes, thorectidaeolide A (1) and 4-acetoxythorectidaeolide A (2), and luffariellolide (11) were among the most potent inhibitors of hypoxia (1% O₂)-induced HIF-1 activation (IC₅₀ values of 3.2, 3.5, and 3.6 μM, respectively). Luffariellolide (11) exhibited a significant level of cytotoxicity that mirrored its HIF-1 inhibitory activity. Neither compound 1, compound 2, nor any of the other less active sesterterpenes suppressed breast tumor T47D or MDA-MB-231 cell viability.
摘要
从海洋海绵 Hyrtios communis 中提取的物质被发现可以抑制 T47D 人乳腺癌肿瘤细胞中转录因子缺氧诱导因子-1（HIF-1）的激活。基于生物测定的分离导致了六种新的（1-6）和五种先前报道的（7-11）甾体类似物以及两种不相关的甾体的鉴定。两种新的甾体，thorectidaeolide A（1）和 4-acetoxythorectidaeolide A（2）以及 luffariellolide（11）是缺氧（1% O₂）诱导的 HIF-1 激活的最强抑制剂之一（IC₅₀ 值分别为 3.2、3.5 和 3.6 μM）。Luffariellolide（11）表现出与其 HIF-1 抑制活性相当的显著细胞毒性。化合物 1、化合物 2 以及任何其他活性较低的甾体都没有抑制乳腺癌 T47D 或 MDA-MB-231 细胞活力。
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