溶酶体mTORC2/PHLPP1/Akt轴：伴侣蛋白介导的自噬的新控制点 - Suppr

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超能文献

Lysosomal mTORC2/PHLPP1/Akt axis: a new point of control of chaperone-mediated autophagy.

作者信息

Arias Esperanza

机构信息

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.

出版信息

Oncotarget. 2015 Nov 3;6(34):35147-8. doi: 10.18632/oncotarget.5903.

DOI:10.18632/oncotarget.5903

PMID:26436591

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4742091/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ea/4742091/cd9270eaa06d/oncotarget-06-35147-g001.jpg

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本文引用的文献

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy.溶酶体mTORC2/PHLPP1/Akt调节伴侣介导的自噬。

Mol Cell. 2015 Jul 16;59(2):270-84. doi: 10.1016/j.molcel.2015.05.030. Epub 2015 Jun 25.

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation.伴侣蛋白介导的自噬通过靶向降解 T 细胞激活的负调控因子来调节 T 细胞反应。

Nat Immunol. 2014 Nov;15(11):1046-54. doi: 10.1038/ni.3003. Epub 2014 Sep 28.

Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation.肝脏中伴侣介导的自噬缺陷会导致代谢失调。

Cell Metab. 2014 Sep 2;20(3):417-32. doi: 10.1016/j.cmet.2014.06.009. Epub 2014 Jul 17.

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives.维甲酸衍生物对伴侣介导的自噬的化学调节。

Nat Chem Biol. 2013 Jun;9(6):374-82. doi: 10.1038/nchembio.1230. Epub 2013 Apr 14.

Chaperone-mediated autophagy is required for tumor growth.伴侣蛋白介导的自噬对于肿瘤生长是必需的。

Sci Transl Med. 2011 Nov 16;3(109):109ra117. doi: 10.1126/scitranslmed.3003182.

Chaperone-mediated autophagy in protein quality control.伴侣蛋白介导的自噬在蛋白质质量控制中的作用。

Curr Opin Cell Biol. 2011 Apr;23(2):184-9. doi: 10.1016/j.ceb.2010.10.009. Epub 2010 Nov 18.

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.Ragulator-Rag 复合物将 mTORC1 靶向到溶酶体表面，并且对于其被氨基酸激活是必需的。

Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.

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