Iyengar Sanjana, Chambers Cindy J, Chang Shurong, Fung Maxwell A, Sharon Victoria R
University of California, Davis.
Dermatol Online J. 2015 Aug 15;21(8):13030/qt35r6z6bx.
Coccidioidomycosis (AKA "Valley fever") is a primary pulmonary infection via airborne spores released from coccidioides immitis in the soil. Reactive cutaneous eruptions resulting from the pulmonary infection are difficult to diagnose because skin biopsies do not contain the organism. We present an adolescent male with primary pulmonary C.immitis infection manifesting with biopsy proven subcorneal pustular dermatosis. Serological studies revealed increasingly positive titers for coccidioidomycosis and symptoms resolved promptly following initiation of systemic antifungal therapy. Our unique case presentation illustrates subcorneal pustular dermatosis as a reactive eruption owing to primary pulmonary coccidioidomycosis. An association between the two conditions warrants further investigation.
球孢子菌病（又称“山谷热”）是一种通过土壤中球孢子菌释放的空气传播孢子引起的原发性肺部感染。肺部感染引起的反应性皮肤疹难以诊断，因为皮肤活检中不含该病原体。我们报告一名青少年男性，患有原发性肺部球孢子菌感染，表现为经活检证实的角膜下脓疱性皮炎。血清学研究显示球孢子菌病滴度呈逐渐上升的阳性，全身抗真菌治疗开始后症状迅速缓解。我们独特的病例展示了角膜下脓疱性皮炎是原发性肺部球孢子菌病引起的一种反应性皮疹。这两种情况之间的关联值得进一步研究。
