De Lucia Rolfe Emanuella, Ong Ken K, Sleigh Alison, Dunger David B, Norris Shane A
Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Box 285, Cambridge, CB2 0QQ, UK.
Department of Paediatrics, University of Cambridge, Cambridge, UK.
BMC Public Health. 2015 Oct 5;15:1013. doi: 10.1186/s12889-015-2147-x.
Individuals of black African ethnicity tend to have less visceral adipose tissue (VAT) but more subcutaneous-abdominal adipose tissue (SCAT) than white Caucasians. However, it is unclear whether such distribution of abdominal fat is beneficial for metabolic disease risk in black individuals. Here we compared the associations between these specific abdominal fat depots, insulin sensitivity and metabolic syndrome risk.
A cross-sectional analysis of 76 black South African young adults (36 men; 40 women) aged 18-19 years participating in the Birth to Twenty Cohort Study had VAT and SCAT measured by MRI. The metabolic syndrome traits (blood pressure, lipid profile, fasting glucose and insulin) were measured and the values were combined into a metabolic syndrome risk score. Fasting glucose and insulin were used to derive the HOMA-index of insulin resistance (HOMA-IR).
Compared to men, women had greater VAT (mean: 16.6 vs. 12.5 cm(2)) and SCAT (median 164.0 vs. 59.9 cm(2)). In men, SCAT (r = 0.50) was more strongly correlated to the metabolic syndrome score (MetS) than was VAT (r = 0.23), and was associated with both MetS (P = 0.001) and HOMA-IR (P = 0.001) after adjustment for VAT and total fat mass. In women, both abdominal fat compartments showed comparable positive correlations with MetS (r = 0.26 to 0.31), although these trends were weaker than in men.
In young black South African adults, SCAT appears to be more relevant than VAT to metabolic syndrome traits.
与白种人相比，非洲裔黑人往往内脏脂肪组织（VAT）较少，但腹部皮下脂肪组织（SCAT）较多。然而，尚不清楚这种腹部脂肪分布对黑人代谢疾病风险是否有益。在此，我们比较了这些特定腹部脂肪库、胰岛素敏感性和代谢综合征风险之间的关联。
对参与“从出生到二十岁队列研究”的76名18 - 19岁南非黑人青年成年人（36名男性；40名女性）进行横断面分析，通过MRI测量VAT和SCAT。测量代谢综合征特征（血压、血脂谱、空腹血糖和胰岛素），并将这些值合并为代谢综合征风险评分。使用空腹血糖和胰岛素得出胰岛素抵抗的HOMA指数（HOMA - IR）。
与男性相比，女性的VAT（平均值：16.6对12.5 cm²）和SCAT（中位数164.0对59.9 cm²）更多。在男性中，SCAT（r = 0.50）与代谢综合征评分（MetS）的相关性比VAT（r = 0.23）更强，并且在调整VAT和总脂肪量后，与MetS（P = 0.001）和HOMA - IR（P = 0.001）均相关。在女性中，两个腹部脂肪区域与MetS均呈现出相当的正相关性（r = 0.26至0.31），尽管这些趋势比男性弱。
在南非年轻黑人成年人中，SCAT似乎比VAT与代谢综合征特征的关联更为密切。
