Sánchez-Pérez Leonor, Irigoyen-Camacho Esther, Sáenz-Martínez Laura, Zepeda Zepeda Marco, Acosta-Gío Enrique, Méndez-Ramírez Ignacio
Area of Research in Clinical Sciences, Health Care Department, Metropolitan Autonomous University - Xochimilco Unit, Mexico City, Mexico.
Microbiology Laboratory, School of Dentistry, National University of Mexico, Mexico City, Mexico.
Int J Paediatr Dent. 2016 Sep;26(5):346-50. doi: 10.1111/ipd.12206. Epub 2015 Oct 5.
To analyze the stability of the unstimulated saliva flow rate (USFR) and the stimulated saliva flow rate (SSFR) in children followed from age 7 to 12 years old.
Longitudinal study. Whole saliva samples were collected from school children (50 girls and 50 boys). Forty-four girls and 32 boys remained in this cohort for 6 years (dropout rate 24%). Variables that could influence USFR or SSFR patterns were analyzed in a repeated-measures manova.
Over a 6-year follow-up, the children's USFR ranged from 0.41 to 0.46 mL/min in the initial and final observation, respectively, and showed no significant differences (P = 0.4455) during the follow-up. The children consistently belonged to one of three distinct SSFR groups (P < 0.0001). A repeated-measures manova model showed that USFR and SSFR were not associated with sex, body mass index, or indoor temperature during sampling.
These results indicate that USFR and SSFR patterns were stable from 7 to 12 years old. This finding may be useful in oral health prevention or treatment and in the search for biomarkers in saliva for screening or diagnostic purposes.
分析7至12岁儿童非刺激性唾液流速（USFR）和刺激性唾液流速（SSFR）的稳定性。
纵向研究。从学童（50名女孩和50名男孩）中采集全唾液样本。44名女孩和32名男孩在该队列中持续观察6年（失访率24%）。在重复测量方差分析中分析可能影响USFR或SSFR模式的变量。
在6年的随访中，儿童的USFR在初始和最终观察时分别为0.41至0.46 mL/分钟，随访期间无显著差异（P = 0.4455）。儿童始终属于三个不同SSFR组之一（P < 0.0001）。重复测量方差分析模型显示，采样期间USFR和SSFR与性别、体重指数或室内温度无关。
这些结果表明，7至12岁儿童的USFR和SSFR模式是稳定的。这一发现可能有助于口腔健康预防或治疗，以及寻找唾液中的生物标志物用于筛查或诊断目的。
