镍过敏是子宫内膜异位症的一个风险因素：一项基于人群的11年巢式病例对照研究。
Nickel Allergy Is a Risk Factor for Endometriosis: An 11-Year Population-Based Nested Case-Control Study.
作者信息
Yuk Jin-Sung, Shin Jong Seung, Shin Ji-Yeon, Oh Eunsuk, Kim Hyunmee, Park Won I
机构信息
Department of Obstetrics and Gynecology, School of Medicine, Eulji University, Daejeon, South Korea; Department of Obstetrics and Gynecology, MizMedi Hospital, Seoul, South Korea.
Department of Obstetrics and Gynecology, Hyundai UVIS hospital, Incheon, South Korea.
出版信息
PLoS One. 2015 Oct 6;10(10):e0139388. doi: 10.1371/journal.pone.0139388. eCollection 2015.
BACKGROUND
A cross-sectional study has reported that nickel allergy is associated with endometriosis. However, causal studies of this association are limited.
OBJECTIVE
The objective of this study was to compare the prevalence of nickel allergy in women with and without endometriosis.
METHODS
We used a National Health Insurance Service (NHIS) sample cohort dataset that included approximately 1 million individuals from South Korea; the data were obtained between January 01, 2002, and December 31, 2013. We selected the endometriosis group according to diagnosis code (N80.X), surgery codes, and drug codes during the years 20092013. The controls were randomly matched to the endometriosis patients at a ratio of 4:1 by age and socioeconomic status. Patients with nickel allergy were defined in the cohort dataset as those with a simultaneous diagnosis code (L23.0) and patch test code during 20022008.
RESULTS
In total, 4,985 women were selected from the NHIS cohort database and divided into an endometriosis group (997 women) and a control group (3,988 women). The number of patients with nickel allergy in the endometriosis group was eight (0.8%), and that in the control group was thirteen (0.3%). After adjustment for age and socioeconomic status, the rate of nickel allergy in was higher in the endometriosis group than in the control group [odds ratio: 2.474; 95% confidence interval: 1.023~5.988; p = 0.044].
CONCLUSIONS
We found that nickel allergy is a risk factor for endometriosis.
背景
一项横断面研究报告称镍过敏与子宫内膜异位症有关。然而，关于这种关联的因果研究有限。
目的
本研究的目的是比较有和没有子宫内膜异位症的女性中镍过敏的患病率。
方法
我们使用了韩国国家健康保险服务（NHIS）样本队列数据集，该数据集包含约100万韩国人；数据收集时间为2002年1月1日至2013年12月31日。我们根据2009年至2013年期间的诊断代码（N80.X）、手术代码和药物代码选择子宫内膜异位症组。对照组按年龄和社会经济地位以4:1的比例与子宫内膜异位症患者随机匹配。队列数据集中镍过敏患者定义为2002年至2008年期间同时具有诊断代码（L23.0）和斑贴试验代码的患者。
结果
总共从NHIS队列数据库中选取了4985名女性，分为子宫内膜异位症组（997名女性）和对照组（3988名女性）。子宫内膜异位症组中镍过敏患者有8名（0.8%），对照组中有13名（0.3%）。在调整年龄和社会经济地位后，子宫内膜异位症组的镍过敏率高于对照组[优势比：2.474；95%置信区间：1.023至5.988；p = 0.044]。
结论
我们发现镍过敏是子宫内膜异位症的一个危险因素。
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