Lin Xiao, Jia Xize, Zang Yu-Feng, Dong Guangheng
Department of Psychology, Zhejiang Normal University, Jinhua China ; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing China.
Cognitive and Brain Disease Research Center, Hangzhou Normal University, Hangzhou China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou China.
Front Psychol. 2015 Sep 28;6:1471. doi: 10.3389/fpsyg.2015.01471. eCollection 2015.
Neuroimaging studies have revealed that the task-related functional brain activities are impaired in internet gaming disorder (IGD) subjects. However, little is known about the alternations in spontaneous brain activities about them. Recent studies have proposed that the brain activities of different frequency ranges are generated by different nervous activities and have different physiological and psychological functions. Thus, in this study, we set to explore the spontaneous brain activities in IGD subjects by measuring the fractional amplitude of low-frequency fluctuation (fALFF), to investigate band-specific changes of resting-state fALFF. We subdivided the frequency range into five bands based on literatures. Comparing to healthy controls, the IGD group showed decreased fALFF values in the cerebellum posterior lobe and increased fALFF values in superior temporal gyrus. Significant interactions between frequency bands and groups were found in the cerebellum, the anterior cingulate, the lingual gyrus, the middle temporal gyrus, and the middle frontal gyrus. Those brain regions are proved related to the executive function and decision-making. These results revealed the changed spontaneous brain activity of IGD, which contributed to understanding the underlying pathophysiology of IGD.
神经影像学研究表明，网络游戏障碍（IGD）患者与任务相关的大脑功能活动受损。然而，关于他们自发脑活动的变化却知之甚少。最近的研究提出，不同频率范围的大脑活动由不同的神经活动产生，具有不同的生理和心理功能。因此，在本研究中，我们通过测量低频振幅分数（fALFF）来探索IGD患者的自发脑活动，以研究静息态fALFF的频段特异性变化。我们根据文献将频率范围细分为五个频段。与健康对照组相比，IGD组小脑后叶的fALFF值降低，颞上回的fALFF值升高。在小脑、前扣带回、舌回、颞中回和额中回发现了频段与组之间的显著交互作用。这些脑区被证明与执行功能和决策有关。这些结果揭示了IGD患者自发脑活动的变化，这有助于理解IGD潜在的病理生理学。
