脊椎动物中光感受器细胞命运的决定
Photoreceptor cell fate specification in vertebrates.
作者信息
Brzezinski Joseph A, Reh Thomas A
机构信息
Department of Ophthalmology, University of Colorado Denver, Aurora, CO 80045, USA.
Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
出版信息
Development. 2015 Oct 1;142(19):3263-73. doi: 10.1242/dev.127043.
Photoreceptors--the light-sensitive cells in the vertebrate retina--have been extremely well-characterized with regards to their biochemistry, cell biology and physiology. They therefore provide an excellent model for exploring the factors and mechanisms that drive neural progenitors into a differentiated cell fate in the nervous system. As a result, great progress in understanding the transcriptional network that controls photoreceptor specification and differentiation has been made over the last 20 years. This progress has also enabled the production of photoreceptors from pluripotent stem cells, thereby aiding the development of regenerative medical approaches to eye disease. In this Review, we outline the signaling and transcription factors that drive vertebrate photoreceptor development and discuss how these function together in gene regulatory networks to control photoreceptor cell fate specification.
光感受器——脊椎动物视网膜中的光敏感细胞——在其生物化学、细胞生物学和生理学方面已经得到了极为充分的表征。因此，它们为探索驱动神经祖细胞在神经系统中分化为特定细胞命运的因素和机制提供了一个绝佳的模型。结果，在过去20年里，在理解控制光感受器特化和分化的转录网络方面取得了巨大进展。这一进展还使得能够从多能干细胞中产生光感受器，从而有助于开发针对眼部疾病的再生医学方法。在本综述中，我们概述了驱动脊椎动物光感受器发育的信号传导和转录因子，并讨论了它们如何在基因调控网络中共同发挥作用以控制光感受器细胞命运的特化。
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