通过α和β阻滞剂、丁酰苯类、5-羟色胺拮抗剂及氯丙嗪的作用评估介导5-羟色胺和儿茶酚胺诱导的血小板聚集的受体特性。
Characterization of receptors mediating 5-hydroxytryptamine- and catecholamine-induced platelet aggregation, assessed by the actions of alpha- and beta-blockers, butyrophenones, 5-HT antagonists and chlorpromazine.
作者信息
Boullin D J, Glenton P A
出版信息
Br J Pharmacol. 1978 Apr;62(4):537-42. doi: 10.1111/j.1476-5381.1978.tb07758.x.
Abstract
1 Blood platelets from normal human volunteers were isolated and aggregated in vitro with 5-hydroxytryptamine (5-HT), noradrenaline (NA), dopamine and N-dimethyldopamine (DMDA). 2 The effects of 5-HT antagonists, alpha- and beta-adrenoceptor blocking agents, butyrophenones and chlorpromazine upon aggregation induced by the four amines were investigated. 3 Only the the 5-HT antagonists, chlorpromazine and spiroperidol were potent inhibitors of 5-HT-induced aggregation, and only phentolamine was a potent inhibitor of the catecholamine-induced aggregation. 4 Evidence was obtained for two populations of receptors, one for 5-HT and one for the three catecholamines.
摘要
1 从正常人类志愿者中分离出血小板，并在体外使其与5-羟色胺（5-HT）、去甲肾上腺素（NA）、多巴胺和N-二甲基多巴胺（DMDA）发生聚集。2 研究了5-HT拮抗剂、α和β肾上腺素能受体阻断剂、丁酰苯类和氯丙嗪对这四种胺诱导的聚集的影响。3 只有5-HT拮抗剂、氯丙嗪和螺哌啶醇是5-HT诱导聚集的有效抑制剂，只有酚妥拉明是儿茶酚胺诱导聚集的有效抑制剂。4 获得了关于两类受体的证据，一类是5-HT受体，另一类是三种儿茶酚胺的受体。
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