Zhao Shuang G, Alexander Neil B, Djuric Zora, Zhou Jessica, Tao Yebin, Schipper Matthew, Feng Felix Y, Eisbruch Avraham, Worden Francis P, Strath Scott J, Jolly Shruti
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
Division of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Head Neck. 2016 Apr;38 Suppl 1(Suppl 1):E1086-96. doi: 10.1002/hed.24162. Epub 2015 Oct 7.
Concurrent chemoradiotherapy (concurrent CRT) to treat head and neck cancer is associated with significant reductions of weight, mobility, and quality of life (QOL). An intervention focusing on functional exercise may attenuate these losses.
We allocated patients to a 14-week functional resistance and walking program designed to maintain physical activity during cancer treatment (MPACT group; n = 11), or to usual care (control group; n = 9). Outcomes were assessed at baseline, and 7 and 14 weeks.
Compared to controls, the MPACT participants had attenuated decline or improvement in several strength, mobility, physical activity, diet, and QOL endpoints. These trends were statistically significant (p < .05) in knee strength, mental health, head and neck QOL, and barriers to exercise.
In this pilot study of patients with head and neck cancer undergoing concurrent CRT, MPACT training was feasible and maintained or improved function and QOL, thereby providing the basis for larger future interventions with longer follow-up. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1086-E1096, 2016.
同步放化疗（同步CRT）治疗头颈癌会导致体重显著下降、活动能力降低及生活质量（QOL）下降。一项针对功能锻炼的干预措施可能会减轻这些损失。
我们将患者分为两组，一组参加为期14周的功能性抗阻和步行计划，旨在在癌症治疗期间保持身体活动（MPACT组；n = 11），另一组接受常规护理（对照组；n = 9）。在基线、第7周和第14周对结果进行评估。
与对照组相比，MPACT参与者在几个力量、活动能力、身体活动、饮食和生活质量终点方面的下降有所减轻或有所改善。这些趋势在膝关节力量、心理健康、头颈生活质量和运动障碍方面具有统计学意义（p < 0.05）。
在这项对头颈癌患者进行同步CRT的试点研究中，MPACT训练是可行的，并且维持或改善了功能和生活质量，从而为未来更大规模、更长随访期的干预措施提供了依据。© 2015威利期刊公司。《头颈》38: E1086 - E1096，2016年。
