De Gaudemaris R, Battistella P, Siche J P, Debru J L, Blatier J F, Mallion J M
Postgrad Med J. 1986;62 Suppl 1:97-100.
Variations in blood pressure were investigated by an automatic, non-invasive ambulatory method in 9 subjects with essential hypertension. Recordings were made after 6 week periods during which captopril was taken either once or twice daily, in a double-blind cross-over study. Although the effects of captopril administration either once or twice daily were broadly similar, there was a significant decrease in diastolic blood pressure values on the once-daily regimen. These results suggests that treatment once a day can advantageously replace twice-daily treatment.
采用自动无创动态血压监测方法，对9例原发性高血压患者的血压变化进行了研究。在一项双盲交叉研究中，在6周的时间段内，患者分别每日服用一次或两次卡托普利后进行记录。尽管每日服用一次或两次卡托普利的效果大致相似，但每日一次服药方案使舒张压值显著降低。这些结果表明，每日一次治疗可有效替代每日两次治疗。
