引起人类和动物尿路感染的大肠杆菌分离株之间的遗传关系。
Genetic relationships among Escherichia coli isolates causing urinary tract infections in humans and animals.
作者信息
Whittam T S, Wolfe M L, Wilson R A
机构信息
Department of Biology, Pennsylvania State University, University Park 16082.
出版信息
Epidemiol Infect. 1989 Feb;102(1):37-46. doi: 10.1017/s0950268800029666.
Abstract
Genetic variation in isolates of Escherichia coli obtained mostly from urinary tract infections in humans and domesticated animals (dogs and cats) was assessed for 16 enzymes using multilocus enzyme electrophoresis to characterize chromosomal genotypes. A total of 148 isolates comprised 63 distinct electrophoretic types (ETs) and about half of the isolates belonged to one of 9 common ETs. A bootstrap analysis of genetic distance between ETs revealed three significant groups of strains. Variation in allele frequencies among groups accounted for 40% of the total genetic diversity. The majority of the common ETs fell into a major cluster of closely related strains. The recovery of multiple isolates of the same electrophoretic types and serotypes from unassociated hosts suggests that these bacteria represent uropathogenic clones that are widely disseminated in humans and animals.
摘要
使用多位点酶电泳法，针对16种酶对主要从人类和家养动物（狗和猫）尿路感染中分离出的大肠杆菌菌株的遗传变异进行评估，以表征染色体基因型。总共148株分离株包含63种不同的电泳类型（ETs），约一半的分离株属于9种常见ETs之一。对ETs之间的遗传距离进行的自展分析揭示了三个显著的菌株组。组间等位基因频率的变异占总遗传多样性的40%。大多数常见的ETs属于一个密切相关菌株的主要聚类。从无关联宿主中分离出相同电泳类型和血清型的多个菌株，表明这些细菌代表了在人类和动物中广泛传播的尿路致病性克隆。
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