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用于小型化3D细胞和组织工程的仿生核壳平台。

A Biomimetic Core-Shell Platform for Miniaturized 3D Cell and Tissue Engineering.

作者信息

Agarwal Pranay, Choi Jung Kyu, Huang Haishui, Zhao Shuting, Dumbleton Jenna, Li Jianrong, He Xiaoming

机构信息

Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210 (USA). Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210 (USA).

Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210 (USA). Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210 (USA). Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210 (USA).

出版信息

Part Part Syst Charact. 2015 Aug;32(8):809-816. doi: 10.1002/ppsc.201500025. Epub 2015 May 12.

Abstract

with a collagen-based core and an alginate hydrogel shell for cell and tissue culture. With this system, chemical and physical properties of extracellular matrix (ECM) in the core microenvironment can be controlled to regulate proliferation and development of cells/tissues under miniaturized three-dimensional (3D) culture.

摘要

具有用于细胞和组织培养的基于胶原蛋白的核心和藻酸盐水凝胶外壳。通过该系统,可以控制核心微环境中细胞外基质(ECM)的化学和物理性质,以在小型化三维(3D)培养下调节细胞/组织的增殖和发育。

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