酪氨酸拉定碱G和H，来自冲绳一种Verongid海绵的新型溴代酪氨酸生物碱。

Tyrokeradines G and H, new bromotyrosine alkaloids from an Okinawan Verongid sponge.

作者信息

Kubota Takaaki, Watase Shinya, Sakai Kanae, Fromont Jane, Gonoi Tohru, Kobayashi Jun'ichi

机构信息

Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan; Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

出版信息

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5221-3. doi: 10.1016/j.bmcl.2015.09.061. Epub 2015 Sep 26.

DOI:10.1016/j.bmcl.2015.09.061

PMID:26459215

Abstract

Two new bromotyrosine alkaloids, tyrokeradines G (1) and H (2), have been isolated from an Okinawan marine sponge of the order Verongida. The structures of 1 and 2 were elucidated on the basis of spectroscopic data. Tyrokeradine G (1) is the first bromotyrosine alkaloid possessing a β-alanine unit, while tyrokeradine H (2) is a rare bromotyrosine alkaloid possessing a N-substituted pyridinium ring. Tyrokeradines G (1) and H (2) showed antifungal activity.

摘要

从冲绳一种属于Verongida目的海洋海绵中分离出了两种新的溴酪氨酸生物碱——酪氨酸角鲨胺G（1）和H（2）。根据光谱数据阐明了1和2的结构。酪氨酸角鲨胺G（1）是首个含有β-丙氨酸单元的溴酪氨酸生物碱，而酪氨酸角鲨胺H（2）是一种罕见的含有N-取代吡啶环的溴酪氨酸生物碱。酪氨酸角鲨胺G（1）和H（2）具有抗真菌活性。