马埃达明 C 和 D，新型溴代酪氨酸生物碱，来自冲绳海洋海绵 sp.，具有独特的四取代吡啶鎓部分。
Ma'edamines C and D, New Bromotyrosine Alkaloids Possessing a Unique Tetrasubstituted Pyridinium Moiety from an Okinawan Marine Sponge sp.
机构信息
Showa Pharmaceutical University , 3-3165 Higashi-Tamagawagakuen , Machida , Tokyo 194-8543 , Japan.
Western Australian Museum , Locked Bag 49 , Welshpool DC , WA 6986 , Australia.
出版信息
Org Lett. 2019 Nov 1;21(21):8824-8826. doi: 10.1021/acs.orglett.9b03457. Epub 2019 Oct 21.
Two new bromotyrosine alkaloids, ma'edamines C and D, were isolated from an Okinawan marine sponge sp. The structures of ma'edamines C and D were elucidated on the basis of spectroscopic data. Ma'edamines C and D were the first natural products possessing a unique tetrasubstituted pyridinium moiety such as -alkyl-3,5-diethyl-2-propylpyridinium and -alkyl-3,5-diethyl-4-propylpyridinium, respectively. Ma'edamines C and D exhibited moderate cytotoxicity against murine leukemia cell line L1210 in vitro.
两种新的溴酪氨酸生物碱，ma'edamines C 和 D，从冲绳海洋海绵 sp 中分离得到。基于光谱数据阐明了 ma'edamines C 和 D 的结构。ma'edamines C 和 D 是分别具有独特的四取代吡啶翁部分的第一个天然产物，如-烷基-3,5-二乙基-2-丙基吡啶翁和-烷基-3,5-二乙基-4-丙基吡啶翁。ma'edamines C 和 D 对体外小鼠白血病细胞系 L1210 显示出中等的细胞毒性。
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