Mattiroli Francesca, D'Arcy Sheena, Luger Karolin
Department of Molecular and Radiobiological Sciences, Howard Hughes Medical Institute, Colorado State University, Fort Collins, CO, USA
Department of Molecular and Radiobiological Sciences, Howard Hughes Medical Institute, Colorado State University, Fort Collins, CO, USA.
EMBO Rep. 2015 Nov;16(11):1454-66. doi: 10.15252/embr.201540840. Epub 2015 Oct 12.
Histone proteins dynamically regulate chromatin structure and epigenetic signaling to maintain cell homeostasis. These processes require controlled spatial and temporal deposition and eviction of histones by their dedicated chaperones. With the evolution of histone variants, a network of functionally specific histone chaperones has emerged. Molecular details of the determinants of chaperone specificity for different histone variants are only slowly being resolved. A complete understanding of these processes is essential to shed light on the genuine biological roles of histone variants, their chaperones, and their impact on chromatin dynamics.
组蛋白动态调节染色质结构和表观遗传信号，以维持细胞内稳态。这些过程需要其特定伴侣蛋白对组蛋白进行可控的时空沉积和移除。随着组蛋白变体的进化，一个功能特异的组蛋白伴侣蛋白网络已经出现。不同组蛋白变体伴侣蛋白特异性决定因素的分子细节正在缓慢得到解析。全面了解这些过程对于阐明组蛋白变体、其伴侣蛋白的真正生物学作用及其对染色质动力学的影响至关重要。
