Keim Sarah A, McNamara Kelly, Kwiek Jesse J, Geraghty Sheela R
1 Center for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital , Columbus, Ohio.
2 Department of Pediatrics, College of Medicine, The Ohio State University , Columbus, Ohio.
Breastfeed Med. 2015 Nov;10(9):416-8. doi: 10.1089/bfm.2015.0098. Epub 2015 Oct 13.
Human milk purchased via the Internet poses a potential risk of recipient infant exposure to drugs, but this risk has not been quantitated by research. Our objective was to test milk we purchased via the Internet for 13 common classes of drugs of abuse to explore the extent of possible exposure to recipient infants.
Samples (n = 102) of milk purchased via the Internet were tested for 13 groups of drugs that are commonly abused using immunoassay screening to identify suspected positives, followed by liquid chromatography/tandem mass spectrometry or gas chromatography/mass spectrometry for confirmation. Sellers' advertisements were abstracted for statements about drug use or abstinence.
Most (71%) sellers stated in their advertisement that they abstained from some type(s) of drugs (prescription or illicit), but 29% indicated nothing about drug use or abstinence. No sellers admitted to illicit drug use in their advertisement. No samples tested positive for the selected drugs of interest (prevalence = 0%; 95% confidence interval, 0.0, 2.9).
We did not detect any of the selected drugs in 102 milk samples. Our sample was too small to detect less commonly used drugs and to provide a narrow confidence interval around the prevalence estimate and did not include milk shared at no cost. Thus, these findings are exploratory and cannot rule out the possibility of drugs being present in other milk available via the Internet.
通过互联网购买的人乳存在受赠婴儿接触药物的潜在风险,但这一风险尚未通过研究进行量化。我们的目的是检测通过互联网购买的乳汁中13种常见滥用药物类别,以探究受赠婴儿可能接触药物的程度。
对通过互联网购买的乳汁样本(n = 102)进行检测,针对13组常见滥用药物采用免疫分析法筛查以识别疑似阳性样本,随后通过液相色谱/串联质谱法或气相色谱/质谱法进行确证。提取卖家广告中关于药物使用或戒毒的陈述。
大多数(71%)卖家在广告中表示他们戒除了某些类型的药物(处方药或非法药物),但29%未提及任何关于药物使用或戒毒的内容。没有卖家在广告中承认使用非法药物。所检测的目标药物样本均未呈阳性(患病率 = 0%;95%置信区间,0.0,2.9)。
我们在102份乳汁样本中未检测到任何一种选定的药物。我们的样本量过小,无法检测到较少使用的药物,也无法在患病率估计值周围提供较窄的置信区间,并且未包括免费分享的乳汁。因此,这些发现具有探索性,不能排除通过互联网获取的其他乳汁中存在药物的可能性。