Hachani Roxanne, Lowdell Mark, Birchall Martin, Hervault Aziliz, Mertz Damien, Begin-Colin Sylvie, Thanh Nguyen Thi Kim
Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, UK.
Nanoscale. 2016 Feb 14;8(6):3278-87. doi: 10.1039/c5nr03867g. Epub 2015 Oct 13.
Iron oxide nanoparticles (IONPs) of low polydispersity were obtained through a simple polyol synthesis in high pressure and high temperature conditions. The control of the size and morphology of the nanoparticles was studied by varying the solvent used, the amount of iron precursor and the reaction time. Compared with conventional synthesis methods such as thermal decomposition or co-precipitation, this process yields nanoparticles with a narrow particle size distribution in a simple, reproducible and cost effective manner without the need for an inert atmosphere. For example, IONPs with a diameter of ca. 8 nm could be made in a reproducible manner and with good crystallinity as evidenced by X-ray diffraction analysis and high saturation magnetization value (84.5 emu g(-1)). The surface of the IONPs could be tailored post synthesis with two different ligands which provided functionality and stability in water and phosphate buffer saline (PBS). Their potential as a magnetic resonance imaging (MRI) contrast agent was confirmed as they exhibited high r1 and r2 relaxivities of 7.95 mM(-1) s(-1) and 185.58 mM(-1) s(-1) respectively at 1.4 T. Biocompatibility and viability of IONPs in primary human mesenchymal stem cells (hMSCs) was studied and confirmed.
通过在高压和高温条件下进行简单的多元醇合成，获得了低多分散性的氧化铁纳米颗粒（IONPs）。通过改变所用溶剂、铁前驱体的量和反应时间，研究了对纳米颗粒尺寸和形态的控制。与热分解或共沉淀等传统合成方法相比，该过程以简单、可重复且经济高效的方式产生粒径分布窄的纳米颗粒，无需惰性气氛。例如，通过X射线衍射分析和高饱和磁化值（84.5 emu g(-1)）证明，可以以可重复的方式制备直径约8 nm且具有良好结晶度的IONPs。IONPs的表面可以在合成后用两种不同的配体进行修饰，这两种配体在水和磷酸盐缓冲盐水（PBS）中提供了功能性和稳定性。它们作为磁共振成像（MRI）造影剂的潜力得到了证实，因为它们在1.4 T时分别表现出7.95 mM(-1) s(-1)和185.58 mM(-1) s(-1)的高r1和r2弛豫率。研究并证实了IONPs在原代人骨髓间充质干细胞（hMSCs）中的生物相容性和活力。
