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一种用于设计和制造无毒钴纳米复合材料的超支化多元醇工艺。

A Hyperbranched Polyol Process for Designing and Manufacturing Nontoxic Cobalt Nanocomposite.

作者信息

Burmatova Anastasia, Khannanov Artur, Gerasimov Alexander, Ignateva Klara, Khaldeeva Elena, Gorovaia Arina, Kiiamov Airat, Evtugyn Vladimir, Kutyreva Marianna

机构信息

A.M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, Russia.

Kazan Research Institute of Epidemiology and Microbiology, 67 Bolshaya Krasnaya Str., 420015 Kazan, Russia.

出版信息

Polymers (Basel). 2023 Jul 30;15(15):3248. doi: 10.3390/polym15153248.

DOI:10.3390/polym15153248
PMID:37571141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10421248/
Abstract

A method for the design and synthesis of a metallopolymer composite (CoNP) based on cobalt nanoparticles using the hyperbranched polyol process was developed. It was shown that hyperbranched polyester polyols in a melted state can be both a reducing agent and a stabilizer of metal nanoparticles at the same time. The mechanism of oxidation of hyperbranched polyol was studied using diffuse reflectance IR spectroscopy. The process of oxidation of OH groups in G4-OH started from 90 °C and finished with the oxidation of aldehyde groups. The composition and properties of nanomaterials were determined with FT-IR and UV-Vis spectroscopy, Nanoparticle Tracking Analysis (NTA), thermogravimetric analysis (TG), powder X-ray diffraction (XRD), NMR relaxation, and in vitro biological tests. The cobalt-containing nanocomposite (CoNP) had a high colloidal stability and contained spheroid polymer aggregates with a diameter of 35-50 nm with immobilized cobalt nanoparticles of 5-7 nm. The values of R and R according to the NMR relaxation method for CoNPs were 6.77 mM·ms × 10 and 4.14 mM·ms × 10 for, respectively. The ratio R/R = 0.61 defines the cobalt-containing nanocomposite as a contrast agent. The synthesized CoNPs were nonhemotoxic (HC > 8 g/mL) multifunctional reagents and exhibited the properties of synthetic modulators of the enzymatic activity of chymosin aspartic proteinase and exhibited antimycotic activity against . The results of the study show the unique prospects of the developed two-component method of the hyperbranched polyol process for the creation of colloidal multifunctional metal-polymer nanocomposites for theranostics.

摘要

开发了一种基于钴纳米颗粒，利用超支化多元醇工艺设计和合成金属聚合物复合材料（CoNP）的方法。结果表明，熔融状态下的超支化聚酯多元醇可同时作为金属纳米颗粒的还原剂和稳定剂。利用漫反射红外光谱研究了超支化多元醇的氧化机理。G4-OH中OH基团的氧化过程从90℃开始，以醛基的氧化结束。通过傅里叶变换红外光谱（FT-IR）、紫外-可见光谱（UV-Vis）、纳米颗粒跟踪分析（NTA）、热重分析（TG）、粉末X射线衍射（XRD）、核磁共振弛豫以及体外生物学测试来确定纳米材料的组成和性质。含钴纳米复合材料（CoNP）具有高胶体稳定性，包含直径为35-50nm的球状聚合物聚集体，其中固定有5-7nm的钴纳米颗粒。根据核磁共振弛豫方法，CoNP的R值和R值分别为6.77 mM·ms×10和4.14 mM·ms×10。R/R=0.61的比值将含钴纳米复合材料定义为一种造影剂。合成的CoNP是非血液毒性的（HC>8 g/mL）多功能试剂，表现出凝乳酶天冬氨酸蛋白酶酶活性合成调节剂的特性，并对……表现出抗真菌活性。研究结果表明，所开发的超支化多元醇工艺双组分方法在制备用于治疗诊断的胶体多功能金属-聚合物纳米复合材料方面具有独特的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ab/10421248/fa8ec9f50806/polymers-15-03248-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ab/10421248/fa8ec9f50806/polymers-15-03248-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ab/10421248/2d8a52b39009/polymers-15-03248-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ab/10421248/ecba83f01565/polymers-15-03248-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ab/10421248/cad4f137b465/polymers-15-03248-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ab/10421248/90dc6863b7e9/polymers-15-03248-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ab/10421248/32716ea8cf07/polymers-15-03248-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ab/10421248/4d8cf7813f83/polymers-15-03248-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ab/10421248/122db6cf0c1f/polymers-15-03248-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0ab/10421248/fa8ec9f50806/polymers-15-03248-g012.jpg

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