Shan Tieying, Shang Wei, Zhang Lei, Zhao Chunfang, Chen Wei, Zhang Yanan, Li Guiying
Department of Histology and Embryology, Hebei Medical University Shijiazhuang, Hebei 050017, China ; Department of Histology and Embryology, Hebei Engineering University Handan 056002, China.
The In Vitro Fertility Center of Obstetrics & Gynecology, PLA Navy General Hospital Beijing 100048, China.
Int J Clin Exp Pathol. 2015 Aug 1;8(8):8948-57. eCollection 2015.
Recent studies have shown that angiotensin II (Ang II) or angiotensin-(1-7) [Ang-(1-7)] has effect on the proliferation and activation of a variety of cells, however, the exact mechanisms that the role of Ang II or Ang-(1-7) in human endometrial stromal cell (ESCs) remains elusive. Here we demonstrated that Ang II could promote proliferation and activation of ESCs, up-regulated the expression of a-SMA, TGF-β1 and IGF-I, increased the secretion of extracellular matrix [Type I collagen (Col I) and fibronectin (FN)] of ESCs; Ang-(1-7) could inhibit Ang II induced the proliferation and activation of ESCs, down-regulated the expression of a-SMA, TGF-β1 and IGF-I, decreased the secretion of extracellular matrix (Col I and FN) of ESCs. These findings suggest that Ang-(1-7) can inhibits Ang II induced the proliferation of ESCs, Ang-(1-7) can inhibits the Ang II induced activation of ESCs and decreases secretion of Col I and FN by suppressing TGF-β1 and IGF-I expression.
近期研究表明，血管紧张素II（Ang II）或血管紧张素-（1-7）[Ang-（1-7）]对多种细胞的增殖和激活有影响，然而，Ang II或Ang-（1-7）在人子宫内膜基质细胞（ESC）中的作用的确切机制仍不清楚。在此我们证明，Ang II可促进ESC的增殖和激活，上调α-SMA、TGF-β1和IGF-I的表达，增加ESC的细胞外基质[I型胶原（Col I）和纤连蛋白（FN）]分泌；Ang-（1-7）可抑制Ang II诱导的ESC增殖和激活，下调α-SMA、TGF-β1和IGF-I的表达，减少ESC的细胞外基质（Col I和FN）分泌。这些发现提示，Ang-（1-7）可抑制Ang II诱导的ESC增殖，Ang-（1-7）可抑制Ang II诱导的ESC激活，并通过抑制TGF-β1和IGF-I表达减少Col I和FN分泌。
