Touboul C, Amate P, Ballester M, Bazot M, Fauconnier A, Daraï E
Service de Gynécologie-Obstétrique, GRC-UPMC 6: Centre Expert en Endometriose (C3E), Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris VI, 4 rue de la Chine, 75020 Paris, France ; Service de Gynécologie-Obstétrique, Hôpital Tenon, 4 rue de la Chine, 75020 Paris, France.
Service de Gynécologie-Obstétrique, GRC-UPMC 6: Centre Expert en Endometriose (C3E), Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris VI, 4 rue de la Chine, 75020 Paris, France.
Int J Chronic Dis. 2013;2013:452134. doi: 10.1155/2013/452134. Epub 2013 Jul 24.
The objective of this study was to evaluate the quality of life (QOL) of patients with deep infiltrating endometriosis (DIE) using EuroQOL (EQ-5D) and its correlation with symptoms and locations of endometriotic lesions. One hundred and fifty-nine patients referred for DIE from January 2011 to April 2011 were prospectively invited to complete questionnaires evaluating symptoms associated with endometriosis as well as the EQ-5D questionnaire and health state. Patients also had locations of DIE evaluated by clinical examination and magnetic resonance imaging (MRI). All 159 patients completed the questionnaires. Item response rate was 91.1%. The most intense symptoms were dysmenorrhea (7.1/10), painful defecation (6.3/10), and fatigue (6.0/10). Mean (SD) scores were 77 (14) for the EQ-5D questionnaire and 63.4 (21) for the health state. A relation was observed between the EQ-5D questionnaire and the presence of dysmenorrhea, dyspareunia, cyclic pelvic pain, painful defecation, and diarrhea or constipation. Vaginal and rectal infiltrations were significantly associated with altered EQ-5D and health state scores. The EQ-5D questionnaire is easy to complete and well related to symptoms of DIE. Rectal and vaginal infiltrations were found to be determinant factors of altered QOL by the EQ-5D questionnaire and health state.
本研究的目的是使用欧洲生活质量量表（EQ-5D）评估深部浸润型子宫内膜异位症（DIE）患者的生活质量（QOL），及其与子宫内膜异位症病变症状和部位的相关性。前瞻性邀请了2011年1月至2011年4月因DIE前来就诊的159例患者，完成评估与子宫内膜异位症相关症状的问卷以及EQ-5D问卷和健康状况问卷。患者还通过临床检查和磁共振成像（MRI）对DIE的部位进行评估。所有159例患者均完成了问卷。条目应答率为91.1%。最严重的症状是痛经（7.1/10）、排便疼痛（6.3/10）和疲劳（6.0/10）。EQ-5D问卷的平均（标准差）得分为77（14），健康状况得分为63.4（21）。观察到EQ-5D问卷与痛经、性交困难、周期性盆腔疼痛、排便疼痛以及腹泻或便秘之间存在关联。阴道和直肠浸润与EQ-5D和健康状况评分的改变显著相关。EQ-5D问卷易于完成，且与DIE的症状密切相关。直肠和阴道浸润被发现是EQ-5D问卷和健康状况所评估的生活质量改变的决定因素。
