铅暴露工人的尿液致突变性检测。
Urinary mutagenicity tests in lead-exposed workers.
作者信息
Apostoli P, Leone R, Porru S, Fracasso M E, Alessio L
机构信息
Cattedra di Medicina del Lavoro, University of Brescia, Italy.
出版信息
Mutat Res. 1989 Mar;222(3):245-51. doi: 10.1016/0165-1218(89)90140-7.
Urinary mutagenic activity detected by the bacterial fluctuation assay, using Salmonella typhimurium TA98 and Escherichia coli WP2 uvrA with and without metabolic activation (S9 mix), was studied in a group of 21 workers exposed to inorganic lead and a control group of 22 non-occupationally exposed subjects. Occupational exposure to inorganic lead had no effect on urinary mutagenicity in the strains considered, with or without metabolic activation. In smokers (exposed and non-exposed), urinary mutagenic activity appeared to increase compared to non-smokers (exposed and non-exposed), only with Salmonella typhimurium TA98 in the presence of S9 mix.
采用鼠伤寒沙门氏菌TA98和大肠杆菌WP2 uvrA，在有或无代谢活化（S9混合物）的情况下，通过细菌波动试验检测尿致突变活性，对一组21名接触无机铅的工人和一组22名非职业暴露受试者进行了研究。无论有无代谢活化，职业性接触无机铅对所考虑菌株的尿致突变性均无影响。在吸烟者（暴露和未暴露）中，与非吸烟者（暴露和未暴露）相比，仅在有S9混合物存在的情况下，用鼠伤寒沙门氏菌TA98检测时，尿致突变活性似乎有所增加。
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