化工行业中对潜在遗传毒性暴露的尿液筛查。
Urinary screening for potentially genotoxic exposures in a chemical industry.
作者信息
Ahlborg G, Bergström B, Hogstedt C, Einistö P, Sorsa M
出版信息
Br J Ind Med. 1985 Oct;42(10):691-9. doi: 10.1136/oem.42.10.691.
Abstract
Mutagenic activity, measured by the bacterial fluctuation assay and thioether concentration in urine from workers at a chemical plant producing pharmaceuticals and explosives, was determined before and after exposure. Of 12 groups only those exposed to trinitrotoluene (n = 14) showed a significant increase in mutagenic activity using Salmonella typhimurium TA 98 without any exogenous metabolic system. The same strain responded only weakly when the S-9 mix was used; with Escherichia coli WP2 uvrA no effect of exposure was observed. Urinary thioether concentration was higher among smokers than among non-smokers, but occupational exposure had no effect. Urinary mutagenicity testing may be a useful tool for screening potentially genotoxic exposures in complex chemical environments.
摘要
采用细菌波动试验和硫醚浓度测定法，对一家生产药品和炸药的化工厂工人接触化学物质前后的致突变活性进行了测定。在12个组中，只有接触三硝基甲苯的那一组（n = 14）在没有任何外源代谢系统的情况下，使用鼠伤寒沙门氏菌TA 98检测出致突变活性显著增加。当使用S-9混合物时，同一菌株的反应较弱；对于大肠杆菌WP2 uvrA，未观察到接触化学物质有任何影响。吸烟者尿中硫醚浓度高于非吸烟者，但职业接触并无影响。尿致突变性检测可能是在复杂化学环境中筛查潜在遗传毒性暴露的有用工具。
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本文引用的文献
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