Rintoul Robert C, Rassl Doris M, Gittins Jacki, Marciniak Stefan J
Department of Thoracic Oncology, Papworth Hospital, Cambridge, UK.
Department of Pathology, Papworth Hospital, Cambridge, UK.
Thorax. 2016 Apr;71(4):380-2. doi: 10.1136/thoraxjnl-2015-207496. Epub 2015 Oct 14.
Malignant pleural mesothelioma causes the greatest societal burden of all the asbestos-related diseases. Progress in better understanding tumour biology will be facilitated by the availability of quality-assured annotated tissue. MesobanK has been created to establish a bioresource of pleural mesothelioma tissue linked to detailed anonymised clinical data. When complete, the bioresource will comprise a 750-patient tissue microarray and prospectively collected tissue, blood and pleural fluid from 300 patients with mesothelioma. Twenty-six new cell lines have also been developed. MesobanK meets all appropriate ethical and regulatory procedures and has recently opened to requests for tissue and data.
恶性胸膜间皮瘤在所有与石棉相关的疾病中造成了最大的社会负担。高质量的注释组织将有助于更深入地了解肿瘤生物学。MesobanK的建立是为了创建一个胸膜间皮瘤组织生物资源库,并将其与详细的匿名临床数据相联系。建成后,该生物资源库将包括一个包含750名患者的组织微阵列,以及从300名间皮瘤患者中前瞻性收集的组织、血液和胸水。此外还开发了26个新的细胞系。MesobanK符合所有适当的伦理和监管程序,最近已开始接受对组织和数据的请求。