Calvi Laura M, Link Daniel C
Department of Medicine and Pharmacology & Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY; and.
Departments of Medicine and Pathology & Immunology, Washington University School of Medicine, St. Louis, MO.
Blood. 2015 Nov 26;126(22):2443-51. doi: 10.1182/blood-2015-07-533588. Epub 2015 Oct 14.
The bone marrow microenvironment contains a heterogeneous population of stromal cells organized into niches that support hematopoietic stem cells (HSCs) and other lineage-committed hematopoietic progenitors. The stem cell niche generates signals that regulate HSC self-renewal, quiescence, and differentiation. Here, we review recent studies that highlight the heterogeneity of the stromal cells that comprise stem cell niches and the complexity of the signals that they generate. We highlight emerging data that stem cell niches in the bone marrow are not static but instead are responsive to environmental stimuli. Finally, we review recent data showing that hematopoietic niches are altered in certain hematopoietic malignancies, and we discuss how these alterations might contribute to disease pathogenesis.
骨髓微环境包含异质性的基质细胞群体，这些细胞组织成龛，支持造血干细胞（HSC）和其他定向造血祖细胞。干细胞龛产生调节HSC自我更新、静止和分化的信号。在这里，我们回顾了最近的研究，这些研究突出了构成干细胞龛的基质细胞的异质性以及它们产生的信号的复杂性。我们强调了新出现的数据，即骨髓中的干细胞龛不是静态的，而是对环境刺激有反应的。最后，我们回顾了最近的数据，这些数据表明造血龛在某些造血恶性肿瘤中发生了改变，并讨论了这些改变可能如何促进疾病的发病机制。
