Valtonen M
Department of Anaesthesiology, University of Turku, Finland.
Acta Anaesthesiol Scand. 1989 Feb;33(2):170-3. doi: 10.1111/j.1399-6576.1989.tb02884.x.
Propofol (2,6-di-isopropylphenol) 1.5-2.0 mg/kg i.v. was compared with thiopentone 3.0-4.0 mg/kg i.v. as an induction agent in anaesthesia for computerised tomography (CT) of the brain in children. Both induction agents were combined with diazepam 0.2 mg/kg i.v. Thirty children (ASA physical status I-II) aged 3 to 10 years and scheduled for elective examination were included in the randomized study. The haemodynamic response to propofol and thiopentone did not differ between the groups. Spontaneous respiration was retained in all patients and no ventilatory support was required during anaesthesia. The incidence of side-effects did not differ between the groups. Pain on injection with propofol was rare (n = 1) after mixing 1 ml lignocaine (1%) with propofol prior to induction. The recovery times were significantly shorter in the propofol than in the thiopentone group. Propofol appears to be a promising alternative for use in short day-case anaesthesia for CT scanning in children.
在儿童脑部计算机断层扫描（CT）麻醉中，将静脉注射1.5 - 2.0毫克/千克的丙泊酚（2,6 - 二异丙基苯酚）与静脉注射3.0 - 4.0毫克/千克的硫喷妥钠作为诱导剂进行比较。两种诱导剂均与静脉注射0.2毫克/千克的地西泮联合使用。随机研究纳入了30名年龄在3至10岁、美国麻醉医师协会（ASA）身体状况为I - II级且计划进行择期检查的儿童。两组对丙泊酚和硫喷妥钠的血流动力学反应无差异。所有患者均保留自主呼吸，麻醉期间无需通气支持。两组副作用发生率无差异。诱导前将1毫升利多卡因（1%）与丙泊酚混合后，注射丙泊酚时疼痛罕见（n = 1）。丙泊酚组的恢复时间明显短于硫喷妥钠组。丙泊酚似乎是儿童CT扫描短程日间手术麻醉中一种有前景的替代药物。
