Kolesov S A, Korkotashvili L V
Klin Lab Diagn. 2015 May;60(5):54-8.
By the present time, a number of articles has been published testifying an extremely high potential of proteome of saliva for diagnostic of many diseases. At the same time, the conclusions can be made from these publications. In particular, to the effect that studies of proteome of saliva are at the stage of data accumulation only. Then, lacking of standardization in collection of samples, techniques of analysis and requirements to representativeness of samplings used as basis for conclusions carry in discrepancies into results acquired by different researchers. Furthermore, physiology and biochemistry of saliva are studied insufficiently as well as characteristics of interaction of proteins of saliva with micro-organisms of oral cavity. All of this establishes obstacles for implementations of achievements in studying of proteome of saliva in diagnostic practice. The solution of these problems will permit making saliva an ideal biological medium for both detection of diseases and prognosis of their course.
到目前为止，已经发表了许多文章，证明唾液蛋白质组在诊断多种疾病方面具有极高的潜力。同时，从这些出版物中可以得出一些结论。特别是，唾液蛋白质组的研究仅处于数据积累阶段。然后，在样本收集、分析技术以及作为结论基础的样本代表性要求方面缺乏标准化，导致不同研究人员获得的结果存在差异。此外，唾液的生理学和生物化学研究不足，唾液蛋白质与口腔微生物相互作用的特征也研究不足。所有这些都为将唾液蛋白质组研究成果应用于诊断实践设置了障碍。解决这些问题将使唾液成为疾病检测和病程预后的理想生物介质。
