Wallington Sherrie F, Dash Chiranjeev, Sheppard Vanessa B, Goode Tawara D, Oppong Bridget A, Dodson Everett E, Hamilton Rhonda N, Adams-Campbell Lucile L
Georgetown-Lombardi Comprehensive Cancer Center, Washington, District of Columbia.
Georgetown-Lombardi Comprehensive Cancer Center, Washington, District of Columbia.
Am J Prev Med. 2016 Jan;50(1):111-117. doi: 10.1016/j.amepre.2015.07.036. Epub 2015 Oct 21.
Research suggests that community involvement is integral to solving public health problems, including involvement in clinical trials-a gold standard. Significant racial/ethnic disparities exist in the accrual of participants for clinical trials. Location and cultural aspects of clinical trials influence recruitment and accrual to clinical trials. It is increasingly necessary to be aware of defining characteristics, such as location and culture of the populations from which research participants are enrolled. Little research has examined the effect of location and cultural competency in adapting clinical trial research for minority and underserved communities on accrual for clinical trials. Utilizing embedded community academic sites, the authors applied cultural competency frameworks to adapt clinical trial research in order to increase minority participation in nontherapeutic cancer clinical trials. This strategy resulted in successful accrual of participants to new clinical research trials, specifically targeting participation from minority and underserved communities in metropolitan Washington, DC. From 2012 to 2014, a total of 559 participants enrolled across six nontherapeutic clinical trials, representing a 62% increase in the enrollment of blacks in clinical research. Embedding cancer prevention programs and research in the community was shown to be yet another important strategy in the arsenal of approaches that can potentially enhance clinical research enrollment and capacity. The analyses showed that the capacity to acquire cultural knowledge about patients-their physical locales, cultural values, and environments in which they live-is essential to recruiting culturally and ethnically diverse population samples.
研究表明，社区参与对于解决公共卫生问题不可或缺，包括参与临床试验——这是一个黄金标准。在临床试验参与者的招募方面存在显著的种族/族裔差异。临床试验的地点和文化因素会影响其招募和参与者入组情况。越来越有必要了解一些界定特征，比如招募研究参与者的人群的地点和文化。很少有研究考察在为少数族裔和服务不足社区调整临床试验研究时，地点和文化能力对临床试验参与者入组情况的影响。作者利用嵌入式社区学术场所，应用文化能力框架来调整临床试验研究，以增加少数族裔参与非治疗性癌症临床试验的比例。这一策略成功地使参与者加入了新的临床研究试验，特别针对华盛顿特区大都市地区少数族裔和服务不足社区的参与情况。从2012年到2014年，共有559名参与者参与了六项非治疗性临床试验，这表明临床研究中黑人的入组人数增加了62%。将癌症预防项目和研究嵌入社区被证明是一系列方法中的又一项重要策略，这些方法有可能提高临床研究的入组率和能力。分析表明，获取有关患者文化知识的能力——他们的实际地点、文化价值观以及他们生活的环境——对于招募具有不同文化和种族背景的人群样本至关重要。
